78583-88-7

Basic information

• Product Name: (2E)-3-chloro-3-(4-nitrophenyl)prop-2-enenitrile
• CAS NO: 78583-88-7
• Molecular Formula: C₉H₅ClN₂O₂
• Molecular Weight: 208.6012
• Mol File: 78583-88-7.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 337.9°C at 760 mmHg
• Flash Point: 158.2°C
• Density: 1.387g/cm³
• Vapor Pressure: 0.000101mmHg at 25°C
• Refractive Index: 1.609
• CAS DataBase Reference: (2E)-3-chloro-3-(4-nitrophenyl)prop-2-enenitrile(CAS DataBase Reference)
• NIST Chemistry Reference: (2E)-3-chloro-3-(4-nitrophenyl)prop-2-enenitrile(78583-88-7)
• EPA Substance Registry System: (2E)-3-chloro-3-(4-nitrophenyl)prop-2-enenitrile(78583-88-7)

Safety Data

• Hazardous Substances Data: 78583-88-7(Hazardous Substances Data)

Upstream product

• 68-12-2 N,N-dimethyl-formamide 
• 100-19-6 (4-nitrophenyl)ethanone 
• 2905-84-2 C₉H₇ClN₂O₃ 
• 2888-10-0 β-Chlor-p-nitro-zimtaldehyd 

Downstream Products

• 91076-99-2 Methyl 3-amino-5-(4-nitrophenyl)thiophene-2-carboxylate 
• 1045703-78-3 3-amino-5-(4-nitrophenyl)-2-selenophenecarbonitrile 
• 3383-43-5 (4-Nitrobenzoyl)acetonitrile 
• 91077-00-8 ethyl 3-amino-5-(4-nitrophenyl)thiophene-2-carboxylate 
• 312529-71-8 2-(4-nitrophenyl)-6,7,8,9-tetrahydrothieno[3',2':4,5]pyrimido[1,2-a]azepin-11(5H)-one 
• 330662-25-4 2-(4-nitrophenyl)-6,7-dihydropyrrolo[1,2-a]thieno[3,2-d]pyrimidin-9(5H)-one 
• 126418-01-7 4-Methyl-N-[1-methyl-5-(4-nitro-phenyl)-1H-pyrazol-3-yl]-benzenesulfonamide 
• 832102-17-7 3-(dimethylamino-methyleneamino)-5-(4-nitro-phenyl)-thiophene-2-carboxylic acid methyl ester 
• 126417-91-2 2-Methyl-5-(4-nitro-phenyl)-2H-pyrazol-3-ylamine 
• 126417-90-1 1-Methyl-5-(4-nitro-phenyl)-1H-pyrazol-3-ylamine 
• 78583-83-2 5-amino-3-(4-nitrophenyl)-1H-pyrazole 

Relevant articles and documents

Novel benzenesulfonamide-bearing pyrazoles and 1,2,4-thiadiazoles as selective carbonic anhydrase inhibitors

Two series comprising 20 novel benzenesulfonamides bearing thioureido-linked pyrazole 8 and amino-1,2,4-thiadiazole 10 were synthesized and assayed as human carbonic anhydrase (hCA) inhibitors against isoforms I and II as well as the tumor-associated isof

Design, Synthesis, and Biological Evaluation of 6-Substituted Thieno[3,2- d]pyrimidine Analogues as Dual Epidermal Growth Factor Receptor Kinase and Microtubule Inhibitors

The clinical evidence for the success of tyrosine kinase inhibitors in combination with microtubule-targeting agents prompted us to design and develop single agents that possess both epidermal growth factor receptor (EGFR) kinase and tubulin polymerization inhibitory properties. A series of 6-aryl/heteroaryl-4-(3′,4′,5′-trimethoxyanilino)thieno[3,2-d]pyrimidine derivatives were discovered as novel dual tubulin polymerization and EGFR kinase inhibitors. The 4-(3′,4′,5′-trimethoxyanilino)-6-(p-tolyl)thieno[3,2-d]pyrimidine derivative 6g was the most potent compound of the series as an antiproliferative agent, with half-maximal inhibitory concentration (IC50) values in the single- or double-digit nanomolar range. Compound 6g bound to tubulin in the colchicine site and inhibited tubulin assembly with an IC50 value of 0.71 μM, and 6g inhibited EGFR activity with an IC50 value of 30 nM. Our data suggested that the excellent in vitro and in vivo profile of 6g may be derived from its dual inhibition of tubulin polymerization and EGFR kinase.

Synthesis of selenophene analogues of the tacrine series: Comparison of classical route and microwave irradiation

New 3-amino-2-selenophenecarbonitriles condensed with cyclanones to afford, in one step, analogues of Tacrine. A comparison between classical heating and microwave irradiation for the Friedlaender condensation is presented. Georg Thieme Verlag Stuttgart.