910791-86-5

Upstream product

• 5720-05-8 4-methylphenylboronic acid 
• 157020-26-3 pyridinium N-<2'-(5'-bromopyridyl)>aminide 
• 148292-03-9 pyridinium N-<2'-(3',5'-dibromopyridyl)>aminide 

Downstream Products

• 1381942-60-4 3-bromo-5-(4-methylphenyl)-2-pyridinamine 
• 1443542-89-9 3-bromo-5-(4-methylphenyl)-2(1H)-pyridinone 
• 1087036-93-8 N-[(3'-bromo-5'-(4''-methylphenyl)pyridin-2'-yl)-(4'''-methylbenzoyl)-amino]pyridinium chloride 
• 503536-74-1 5-(4-methylphenyl)pyridin-2-ylamine 
• 1087037-18-0 3-(4''-methylphenyl)-dipyrido[1,2-b;3',2'-d]pyrazole 

Relevant academic research and scientific papers

A facile synthesis of 3,5-halo and aryl 1H-pyridin-2-ones from pyridinium N-(pyridin-2-yl)aminide

The synthesis of halogenated and arylated 1H-pyridin-2-ones starting from pyridinium N-(pyridin-2-yl)aminides is described. The synthetic pathway involves the reaction of pyridinium N-(5-bromopyridin-2-yl)aminide, N-(3-bromo-5- chloropyridin-2-yl)aminide or N-(3,5-dibromopyridin-2-yl)aminide with different boronic acids to afford monosubstituted and disubstituted aminides in good yields. An additional bromination in the 3-position of N-(5-arylpyridin-2-yl) aminides was performed. Finally, reduction of the N-N bond followed by the reaction of the corresponding 2-aminopyridines with sodium nitrite/sulfuric acid in water yields 3,5-disubstituted 1H-pyridin-2-ones in good yields.

Regioselective Suzuki coupling on pyridinium N-(3,5-dibromoheteroar-2-yl)aminides

A regioselective Suzuki-Miyaura cross-coupling reaction on 3′,5′-dibromo pyridinium N-(2′-azinyl)aminides is reported. A series of 3′-aryl(or heteroaryl)-5′-bromo-pyridinium N-(2′-pirazinyl)aminides were obtained in good yields. Two isomeric 3′,5′-diaryl