91086-68-9Relevant academic research and scientific papers
Synthesis of 2-thiophenecarboxylic and 2,5-thiophenedicarboxylic acid esters via the reaction of thiophenes with the CCl4-ROH reagent in the presence of vanadium, iron, and molybdenum catalysts
Khusnutdinov,Shchadneva,Baiguzina,Mukminov,Mayakova,Smirnov,Dzhemilev
experimental part, p. 471 - 478 (2010/03/31)
2-Thiophenecarboxylic and 2,5-thiohenedicarboxylic acid esters were synthesized via the reaction of thiophene with the CCl4-ROH-catalyst system, with a total yield of 44-85%. A possible reaction scheme includes the successive steps of alkylation of thiophene with carbon tetrachloride, leading to 2-trichloromethylthiophene, and alcoholysis of the product giving the corresponding 2-thiophenecarboxylate. The best catalysts for this reaction are VO(acac)2, Fe(acac)3, and Mo(CO)6.
A Facile Preparation of β-Alkyl-β-phenylthio-α,β-unsaturated Carbonyl Compounds in a Synthesis of Alkyl Substituted Thiophene-2-carboxylic Esters
Tso, Hsi-Hwa,Chen, Yu-Jiun
, p. 13 - 16 (2007/10/02)
A facile two-step or three-step one-flask procedure for a synthesis of β-alkyl-β-phenylthio-α,β-unsaturated carbonyl compounds (3a-j) from readily prepared 3-methoxy-1-phenylthio-1-propyne (1) is described.Condensation of 3a-j with methyl thioglycolate readily affords a number of 3-alkyl- and 3,5-dialkylthiophene-2-carboxylic methyl esters.
