910920-84-2

Upstream product

• 910920-82-0 2-(4-iodo-3-methoxy-phenyl)-5,5-dimethyl-[1,3]dioxane 
• 910920-83-1 5-chloro-3-[4-(5,5-dimethyl-[1,3]dioxan-2-yl)-2-methoxy-phenyl]-3-hydroxy-1,3-dihydro-indol-2-one 
• 29802-22-0 (S)-pyrrolidin-2-carboxylic acid dimethylamide 
• 135242-71-6 3-hydroxy-4-iodobenzaldehyde 
• 121404-83-9 4-iodo-3-methoxybenzaldehyde 
• 101560-86-5 5-chloroisatine sodium salt 

Downstream Products

• 910920-85-3 C₂₃H₂₄ClN₃O₄ 

Relevant academic research and scientific papers

Potent and selective oxindole-based vasopressin 1b receptor antagonists with improved pharmacokinetic properties

Herein we report the discovery of a novel series of vasopressin 1b (V1b) receptor antagonists, starting from potent but metabolically labile oxindole SSR149415. Masking the proline N,N-dimethyl amide moiety as an oxazole and attaching a benzylic amine moiety to the northern phenyl ring resulted in potent and selective V1b receptor antagonists with improved metabolic stability and improved pharmacokinetic properties in rat. Compound 18c was found to be efficacious in a rat model of anti-depressant activity.