91093-42-4

Usage

Uses

Used in Pharmaceutical Industry:
2-AMINO-4-PHENYLPYRIMIDINE-5-CARBOXYLIC ACID is used as a building block for the synthesis of various biologically active compounds, including pharmaceutical drugs. Its unique structure allows for the development of new chemical entities with potential therapeutic applications.
Used in Agrochemical Industry:
2-AMINO-4-PHENYLPYRIMIDINE-5-CARBOXYLIC ACID is used as a building block for the synthesis of various biologically active compounds, including pesticides. Its versatile chemical properties enable the creation of new agrochemicals with improved efficacy and selectivity.

InChI:InChI=1/C11H9N3O2/c12-11-13-6-8(10(15)16)9(14-11)7-4-2-1-3-5-7/h1-6H,(H,15,16)(H2,12,13,14)

Upstream product

• 614-27-7 methyl 3-oxo-3-phenylpropionate 
• 66129-60-0 ethyl-3-(dimethylamino)-2-(phenylcarbonyl)prop-2-enoate 

Downstream Products

• 2305-87-5 4-phenylpyrimidin-2-amine 

Relevant academic research and scientific papers

NEW MALONITRILE DERIVATIVES

The invention relates to a compound of formula (I) wherein R1-R4 and A1-A2 are as defined in the description and in the claims. The compound of formula (I) can be used as a medicament.

Reaction of 2-Dimethylaminomethylene-1,3-diones with Dinucleophiles. VIII. Synthesis of Ethyl and Methyl 2,4-Disubstituted 5-Pyrimidinecarboxylates

Reaction of ethyl or methyl 2-dimethylaminomethylene-3-oxoalkanoates with N-C-N dinucleophiles such as guanidine, acetamidine or benzamidine afforded in high yields the relative esters of 4-substituted 2-amino-, 2-methyl- or 2-phenyl-5-pyrimidinecarboxylic acids, respectively.These esters were hydrolyzed to the corresponding carboxylic acids, which were converted by heating to 4-substituted 2-pyrimidinamines, 2-methyl or 2-phenylpyrimidines, respectively, generally in excellent yields.The 4-unsubstituted ethyl 2-amino-, 2-methyl- and 2-phenyl-5-pyrimidinecarboxylateswere obtained in moderate yields by reaction of the above dinucleophiles with ethyl 2,2-diformylacetate.These esters were hydrolyzed and the corresponding acids (with the exception of the 2-methyl derivative) were decarboxylated to give 2-pyrimidinamine and 2-phenylpyrimidine in satisfactory yields.