91098-88-3

Upstream product

• 97563-45-6 1-cyclohexylprop-2-yn-1-ol 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 2043-61-0 cyclohexanecarbaldehyde 
• 74-86-2 acetylene 

Downstream Products

• 125974-12-1 cis-2-(3-((tert-Butyldimethylsilyl)oxy)-3-cyclohexyl-1-propynyl)-3-cyclopenten-1-ol 
• 125974-13-2 cis-4-(3-((tert-Butyldimethylsilyl)oxy)-3-cyclohexyl-1-propynyl)-2-cyclopenten-1-ol 
• 105880-44-2 C₂₅H₄₂O₄Si 
• 105880-45-3 C₂₅H₄₂O₄Si 
• 125974-14-3 trans-4-(3-((tert-Butyldimethylsilyl)oxy)-3-cyclohexyl-1-propynyl)-2-cyclopentenyl Benzoate 
• 125974-15-4 trans-4-(3-((tert-Butyldimethylsilyl)oxy)-3-cyclohexyl-1-propynyl)-2-cyclopenten-1-ol 
• 105880-66-8 RS₉₃₅₂₀ 
• 105880-50-0 4-[(1S,2S,3R,6S)-2-((S)-3-Cyclohexyl-3-hydroxy-prop-1-ynyl)-3-hydroxy-bicyclo[4.2.0]oct-(7E)-ylidene]-butyric acid 
• 105284-21-7 butanoic acid, 4-[(1S,2S,3R,6S)-2-[(3S)-3-cyclohexyl-3-hydroxy-1-propynyl]-3-hydroxybicyclo[4.2.0]oct-7-ylidene]-(4Z) 
• 108147-34-8 (1S,2R,3S,6R)-2-((S)-3-Cyclohexyl-3-hydroxy-prop-1-ynyl)-3-hydroxy-bicyclo[4.2.0]octan-7-one 
• 108147-32-6 (1S,2R,3S,6R)-2-((R)-3-Cyclohexyl-3-hydroxy-prop-1-ynyl)-3-hydroxy-bicyclo[4.2.0]octan-7-one 
• 108147-33-7 (1R,2S,3R,6S)-2-((R)-3-Cyclohexyl-3-hydroxy-prop-1-ynyl)-3-hydroxy-bicyclo[4.2.0]octan-7-one 
• 105803-40-5 3-hydroxy acetal silyl ether 
• 105803-42-7 (3'S,1S,2S,3R,6S)-2-(3'-cyclohexyl-3'-hydroxyprop-1'-ynyl)-3-hydroxybicyclo<4.2.0>octan-7-one 

Relevant academic research and scientific papers

Novel substituted (4.2.0)bicyclooctane derivatives with valuable therapeutic properties

Compounds useful in treating cardiovascular disorders such as thrombosis, hypertension and atherosclerosis are depicted in formulas (1), (2) and (3): STR1 wherein: A is --C C--, trans --HC=CH--, --CH2 CH2 -- or --CH=CHCH2 --; X is lower alkoxy, hydroxy, or (2,2,2)-trifluoroethoxy; Y is hydrogen, exo-(lower alkyl) or endo-(lower alkyl); is an integer of 2-4; R1 is --CH2 OH, --CHO, --CO2 R or --CO2 H, and the olefin formed by the R1 (CH2)n CH= moiety is either (E) or (Z); R2 is hydrogen or methyl, or optionally --CH=CH2 when A is --CH=CHCH2 --; and R3 is linear or branched alkyl, alkenyl or alkynyl having 5-10 carbon atoms, STR2 --(CH2)m -phenyl or CH2 O-phenyl; in which each phenyl may be optionally substituted with lower alkyl, lower alkoxy, trifluoromethyl, or halogen; in which: a is an integer of 0, 1 or 2; b is an integer of 3-7; m is an integer of 0, 1 or 2; and R is STR3 wherein x is STR4 in which each R4 is independently hydrogen or lower alkyl having 1-6 carbon atoms, and the pharmaceutically acceptable, non-toxic salts and esters thereof.

Potent Prostacyclin Analogues Based on the Bicyclooctane Ring System

The novel and biologically active prostacyclin mimetics 2 and 29 were prepared in a sequence based on the regioselective opening of epoxide 7 with a lithium acetylide in the presence of boron trifluoride etherate.The regioselectivity of epoxide opening wa

Novel 8-(lower alkyl)bicyclo[4.2.0]octane derivatives with valuable therapeutic properties

Compounds useful in treating cardiovascular disorders such as thrombosis, hypertension, and atherosclerosis are compounds depicted in formulas (1), (2), and (3): STR1 wherein: Y is exo-(lower alkyl) or endo-(lower alkyl); n is 2 or 3; R1 is CH2 OH, CHO, CO2 R or CO2 H; R2 is hydrogen or methyl; and R3 is linear or branched alkyl having 5-10 carbon atoms, STR2 or --(CH2)m -phenyl optionally substituted with lower alkyl, lower alkoxy, trifluoromethyl, or halogen, in which a is 0, 1 or 2; b is 3-7; m is 1 or 2; and R is STR3 wherein X is STR4 in which each R4 is independently hydrogen or lower alkyl having 1-6 carbon atoms, and the pharmaceutically acceptable, non-toxic salts and esters thereof.

Novel [4,2,0]bicyclooctane derivatives with valuable therapeutic properties

Compounds useful in treating cardiovascular disorders such as thrombosis, hypertension, and atherosclerosis are compounds depicted in formulas (1), (2), and (3): STR1 wherein: n is 2 or 3; R1 is CH2 OH, CHO, CO2 R or CO2 H; R2 is hydrogen or methyl; and R3 is linear or branched alkyl having 5-10 carbon atoms, STR2 optionally substituted with lower alkyl, lower alkoxy, trifluoromethyl, or halogen, in which a is 0, 1 or 2; b is 3-7; m is 1 or 2; and R is STR3 in which each R4 is independently hydrogen or lower alkyl having 1-6 carbon atoms, and the pharmaceutically acceptable, non-toxic salts and esters thereof.

[3.2.0]Bicycloheptanone oxime ethers with valuable therapeutic properties

Compounds useful in treating cardiovascular disorders are the carboxylic acids depicted in formulas (1) and (2) STR1 as well as their pharmaceutically acceptable, non-toxic salts and esters, wherein: n is an integer from one to four; R1 is hydroxy; R2 is hydrogen; or R1 and R2 together are an oxo group; R3 is STR2 wherein A is --CH2 --CH2 --; trans--CH=CH--; --C C--; and R4 is linear or branched alkyl of one to twelve carbons, preferably 1-10 carbons, most preferably 3-8 carbons, cycloalkyl of three to eight carbons; phenyl optionally substituted with one or two identical substituents selected from the group consisting of lower alkyl, lower alkoxy, hydroxy, trifluoromethyl, and halo; or phenylloweralkyl optionally substituted with one or two identical substituents selected from the group consisting of lower alkyl, lower alkoxy, hydroxy, trifluoromethyl, and halo.

OPENING OF A 1,3-DIOXOLANE BY NUCLEOPHILIC ATTACK AT A KETAL METHYLENE

A novel type of opening of an ethylene ketal has been observed in the reaction of 1 with alane RAlMe2.The reaction is explained in terms of a nucleophilic attack on the ketal methylene synchronous with participation by one of the ketal oxygens in the open

(3.2.0) Bicycloheptanone oxime ethers with therapeutic properties

Compounds useful in treating cardiovascular disorders are the carboxylic acids depicted in formulas (1) and (2) STR1 as well as their pharmaceutically acceptable, non-toxic salts and esters, wherein: n is an integer from one to four; R1 is hydroxy; R2 is hydrogen; or R1 and R2 together are an oxo group; R3 is STR2 wherein A is --CH2 --CH2 --; trans-CH=CH--; --C C--; and R4 is linear or branched alkyl of one to twelve carbons, cycloalkyl of three to eight carbons; phenyl optionally substituted with one or two identical substituents selected from the group consisting of lower alkyl, lower alkoxy, hydroxy, trifluoromethyl, and halo; or optionally substituted phenylalkyl.