911066-05-2

Upstream product

• 738-70-5 5-(3,4,5-trimethoxybenzyl)pyrimidine-2,4-diamine 
• 100-52-7 benzaldehyde 
• 911066-02-9 N²,N⁴-Bis-[1-phenyl-meth-(E)-ylidene]-5-(3,4,5-trimethoxy-benzyl)-pyrimidine-2,4-diamine 

Relevant academic research and scientific papers

Novel pyrimidine derivatives for drug design

TRIMETHOPRIM [2,4-diamino-5-(3,4,5-trimethoxybenzyl) pyrimidine] (1 a) reacted with benzaldehyde and acetic anhydride to afford 2,4-disubstituted amino derivatives (1b-c). The methylene group of compounds (1a-c) was oxidized by convenient and simple method using sodium dichromate and acetic acid to give the corresponding ketonic derivatives (2a-c). (2a) was converted to the corresponding thio derivative using phosphrous pentasulphide or Lawsson's reagent which is the target of our work. The reaction of ketonic derivatives (2a-c) with different nitrogen nucleophiles have been also reported.