911124-05-5

Basic information

• Product Name: tert-butyl 4-amino-3-fluoro-5-iodobenzylcarbamate
• Synonyms: tert-butyl 4-amino-3-fluoro-5-iodobenzylcarbamate
• CAS NO: 911124-05-5
• Molecular Weight: 366.174
• Mol File: 911124-05-5.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: tert-butyl 4-amino-3-fluoro-5-iodobenzylcarbamate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl 4-amino-3-fluoro-5-iodobenzylcarbamate(911124-05-5)
• EPA Substance Registry System: tert-butyl 4-amino-3-fluoro-5-iodobenzylcarbamate(911124-05-5)

Safety Data

• Hazardous Substances Data: 911124-05-5(Hazardous Substances Data)

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 1165739-58-1 4-(aminomethyl)-2-fluoro-6-iodoaniline hydrochloride 
• 849353-46-4 4-amino-3-fluoro-5-iodo-benzonitrile 

Downstream Products

• 911124-06-6 (4-amino-3-fluoro-5-vinylbenzyl)carbamic acid t-butyl ester 
• 953090-83-0 tert-butyl 3-fluoro-5-iodo-4-(methylsulfonamido)-benzylcarbamate 

Relevant articles and documents

Design, synthesis, and biological evaluation of novel diarylalkyl amides as TRPV1 antagonists

We have developed a new class of diarylalkyl amides as novel TRPV1 antagonists. They exhibited potent 45Ca2+ uptake inhibitions in rat DRG neuron. In particular, the amide 59 was identified as a potent antagonist with IC50 of 57 nM. The synthesis and structure-activity relationship of the diarylalkyl amides are also described.

Novel compounds, isomer thereof or pharmaceutically acceptable salts thereof as vanilloid receptor antagonist; and a pharmaceutical composition containing the same

This present invention relates to compounds of formula (I), in which R3 represents C2-C5 alkenyl or C2-C5 alkynyl and the other variables are as defined in the claims, isomers thereof or pharmaceutically acceptable salts thereof as vanilloid receptor (Vanilloid Receptor 1; VR1; TRPV1) antagonists; and a pharmaceutical composition containing the same. The present invention provides a pharmaceutical composition for preventing or treating pain, inflammatory disease of the joints, urinary bladder hypersensitivity including urinary incontinence, stomach duodenal ulcer, irritable bowel syndrome, inflammatory bowel disease, neurotic/allergic/inflammatory skin disease, psoriasis, asthma, chronic obstructive pulmonary disease, pruritus or prurigo.