911138-63-1

Upstream product

• 29024-92-8 1-hydroximino-1-phenylacetone 
• 26028-43-3 1,3,5-triallylhexahydro-1,3,5-triazine 
• 25355-34-4 1-phenyl-propane-1,2-dione 1-oxime 

Downstream Products

• 36176-39-3 1,3-dihydro-5-methyl-4-phenyl-1-(prop-2-enyl)-2H-imidazol-2-one 
• 1266332-45-9 C₃H₂F₆O₂*C₁₃H₁₄N₂O 

Relevant academic research and scientific papers

First synthesis of the N(1)-bulky substituted imidazole 3-oxides and their complexation with hexafluoroacetone hydrate

Synthesis of new 2-unsubstituted imidazole 3-oxides bearing bulky substituents at the N(1) atom, based on the condensation of appropriate alkylamines, formaldehyde, and corresponding a-(hydroxyimino)ketone, is described. Treatment of imidazole 3-oxides with hexafluoroacetone hydrate (HFAH) yields crystalline 1:1 complexes in nearly quantitative yields. Heating of isolated complexes possessing phenyl ring at the C(4) atom of imidazole ring, results in their isomerization into imidazol-2-ones in fair yields. The formation of analogous complexes of HFAH with other azole N-oxides is also described. ARKAT-USA, Inc.

Reactions of 2-unsubstituted 1H-imidazole 3-oxides with 2,2-bis(trifluoromethyl)ethene-1,1-dicarbonitrile: A stepwise 1,3-dipolar cycloaddition

The reaction of 1,4,5-trisubstituted 1H-imidazole-3-oxides 1 with 2,2-bis(trifluoromethyl)ethene-1,1-dicarbonitrile (7, BTF) yielded the corresponding 1,3-dihydro-2H-imidazol-2-ones 10 and 2-(1,3-dihydro-2H-imidazol- 2-vlidene)malononitriles 11, respectiv