25355-34-4Relevant academic research and scientific papers
1,2,5-thiadiazole-2 oxide analogue and application thereof
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Paragraph 0052; 0053-0056; 0071; 0072; 0073; 0074; 0076, (2017/07/31)
The invention belongs to the field of pharmaceutical chemistry and discloses a 1,2,5-thiadiazole-2 oxide analogue and application thereof. The compound blocks a normal redox equilibrium process of schistosoma cells to kill schistosoma. When the drug conce
Transition-Metal-Free Deacylative Cleavage of Unstrained C(sp3)-C(sp2) Bonds: Cyanide-Free Access to Aryl and Aliphatic Nitriles from Ketones and Aldehydes
Ge, Jing-Jie,Yao, Chuan-Zhi,Wang, Mei-Mei,Zheng, Hong-Xing,Kang, Yan-Biao,Li, Yadong
, p. 228 - 231 (2016/02/03)
A transition-metal-free deacylative C(sp3)-C(sp2) bond cleavage for the synthetically practical oxidative amination of ketones and aldehydes to nitriles is first described, using cheap and commercially abundant NaNO2 as the oxidant and the nitrogen source. Various nitriles bearing aryl, heteroaryl, alkyl, and alkenyl groups could be smoothly obtained from ketones and aldehydes in high yields, avoiding highly toxic cyanides or transition metals.
FACILE DIRECT α-OXIMATION OF KETONES USING t-BUTYL THIONITRATE
Kim, Yong Hae,Park, Young Jun,Kim, Kweon
, p. 2833 - 2836 (2007/10/02)
Various ketones containing methylene groups at α-position were found to react with t-butyl thionitrate at 0 deg C in tetrahydrofuran to give the corresponding α-oximino-ketones in excellent yield.
