911223-07-9

Upstream product

• 625114-66-1 (5-methylpyrazin-2-yl)-carbamic acid phenyl ester 
• 911223-06-8 (R)-3-(2-amino-4-chloro-phenoxymethyl)-morpholine-4-carboxylic acid tert-butyl ester 
• 19994-56-0 2-Amino-3-cyano-5-methylpyrazine 1-oxide 
• 345-18-6 2-fluoro-5-chloronitrobenzene 
• 911223-05-7 (R)-3-(4-chloro-2-nitro-phenoxymethyl)-morpholine-4-carboxylic acid tert-butyl ester 
• 5521-58-4 5-methylpyrazin-2-amine 
• 869681-70-9 (R)-morpholine-3,4-dicarboxylic acid 4-tert-butyl ester 
• 714971-28-5 (S)-3-(hydroxymethyl)morpholine-4-carboxylic acid tert-butyl ester 

Relevant academic research and scientific papers

HETEROARYL UREA DERIVATIVES USEFUL FOR INHIBITING CHKl

Substituted urea compounds useful in the treatment of diseases and conditions related to DNA damage or lesions in DNA replication are disclosed. Methods of making the compounds, and their use as therapeutic agents, for example, in treating cancer and other diseases characterized by defects in DNA replication, chromosome segregation, or cell division, also are disclosed.