911291-94-6

Upstream product

• 100-46-9 benzylamine 
• 552-89-6 2-nitro-benzaldehyde 

Downstream Products

• 95982-61-9 o-nitro-N-benzyl(benzylamine) 
• 195611-43-9 diethyl 1-(N-benzylamino)-2-nitrobenzylphosphonate 
• 133390-28-0 2-(o-acetylaminobenzyl)-4-phenyl-1,2,3,4-tetrahydroisoquinoline 
• 133406-89-0 2-(o-aminobenzyl)-4-phenyl-1,2,3,4-tetrahydroisoquinoline 
• 133390-35-9 2-[Benzyl-(2-nitro-benzyl)-amino]-1-phenyl-ethanol 
• 133390-34-8 2-[Benzyl-(2-nitro-benzyl)-amino]-1-phenyl-ethanone 
• 133390-25-7 2-[(2-Amino-benzyl)-benzyl-amino]-1-phenyl-ethanol 
• 133390-37-1 ethyl 4-phenyl-1,2,3,4-tetrahydroisoquinoline-2-carboxylate 
• 90562-37-1 N-(2-chloromethylphenyl)acetamide 
• 75626-12-9 4-phenyl-1,2,3,4-tetrahydroisoquinoline 
• 75063-84-2 2-amino-3-benzyl-3,4-dihydroquinazoline 
• 75063-86-4 2-acetylamino-3-benzyl-3,4-dihydroquinazoline 
• 76285-51-3 3-benzyl-2-ethylamino-3,4-dihydroquinazoline 
• 76285-39-7 3-benzyl-3,4-dihydroquinazoline 

Relevant academic research and scientific papers

The cleavage of 1-amino-2'-nitrobenzylphosphonates in a basic medium. Formation of the 3-amino-2,1-benzisoxazole derivatives

Treatment of 1-amino-2'-nitrobenzylphosphonic acids with aqueous sodium hydroxide caused a C-P bond cleavage, with formation of 3-amino-2,1-benzisoxazole derivatives (3). The leaving phosphorus moiety was identified here as phosphoric acid. In the case of basic hydrolysis of corresponding esters, new cyclic phosphorus compounds (derivatives of benzoxazaphosphorin-3,1,2 P(v)-one-2) were obtained. The cyclic products were formed as a result of the subsequent reaction of anthranil derivatives with leaving phosphorus fragment, presumably metaphosphate, These benzoxazaphosphorins (cormpounds 4) were converted by means of aqueous hydrochloric acid to 3-amino-2,1-benzisoxazole derivatives.

CYCLIZATION OF N-(2-AMINOBENZYL) BENZYLAMINO-1-PHENYL-1-ETHANOLS AND DEBENZYLATION OF THE RESULTING TETRAHYDROISOQUINOLINE DERIVATIVES

Debenzylation reactions of 2-(o-aminobenzyl)-4-phenyl-1,2,3,4-tetrahydroisoquinolines (3a, b) and their N-acetyl derivatives (4a, b), obtained by the cyclization of N-(2-aminobenzyl)benzylamino-1-phenyl-1-ethanols (1), were studied.