95982-61-9

Basic information

• Product Name: Benzenemethanamine, 2-nitro-N-(phenylmethyl)-
• CAS NO: 95982-61-9
• Molecular Formula: C14H14N2O2
• Molecular Weight: 242.277
• Mol File: 95982-61-9.mol
• Article Data: 14

Chemical Properties

• CAS DataBase Reference: Benzenemethanamine, 2-nitro-N-(phenylmethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenemethanamine, 2-nitro-N-(phenylmethyl)-(95982-61-9)
• EPA Substance Registry System: Benzenemethanamine, 2-nitro-N-(phenylmethyl)-(95982-61-9)

Safety Data

• Hazardous Substances Data: 95982-61-9(Hazardous Substances Data)

Upstream product

• 190257-36-4 N-benzyl-N-[(2-nitrophenyl)methylidene]amine 
• 612-25-9 2-Nitrobenzyl alcohol 
• 100-46-9 benzylamine 
• 3958-60-9 2-nitrophenylmethyl bromide 
• 552-89-6 2-nitro-benzaldehyde 
• 612-23-7 2-nitrobenzyl chloride 
• 911291-94-6 benzyl-(2-nitro-benzyliden)-amine 

Downstream Products

• 20878-80-2 3-benzyl-3,4-dihydro-2(1H)-quinazolinone 
• 190257-36-4 N-benzyl-N-[(2-nitrophenyl)methylidene]amine 
• 1310480-61-5 1-benzyl-3,3-dimethyl-1-(2-nitrobenzyl)urea 
• 133390-28-0 2-(o-acetylaminobenzyl)-4-phenyl-1,2,3,4-tetrahydroisoquinoline 
• 133406-89-0 2-(o-aminobenzyl)-4-phenyl-1,2,3,4-tetrahydroisoquinoline 
• 133390-35-9 2-[Benzyl-(2-nitro-benzyl)-amino]-1-phenyl-ethanol 
• 133390-25-7 2-[(2-Amino-benzyl)-benzyl-amino]-1-phenyl-ethanol 
• 90562-37-1 N-(2-chloromethylphenyl)acetamide 
• 75626-12-9 4-phenyl-1,2,3,4-tetrahydroisoquinoline 
• 75063-84-2 2-amino-3-benzyl-3,4-dihydroquinazoline 
• 75063-86-4 2-acetylamino-3-benzyl-3,4-dihydroquinazoline 
• 76285-51-3 3-benzyl-2-ethylamino-3,4-dihydroquinazoline 
• 76285-39-7 3-benzyl-3,4-dihydroquinazoline 

Relevant articles and documents

High-Throughput Screening of Reductive Amination Reactions Using Desorption Electrospray Ionization Mass Spectrometry

This study describes the latest generation of a high-throughput screening system that is capable of screening thousands of organic reactions in a single day. This system combines a liquid handling robot with desorption electrospray ionization (DESI) mass spectrometry (MS) for a rapid reaction mixture preparation, accelerated synthesis, and automated MS analysis. A total of 3840 unique reductive amination reactions were screened to demonstrate the throughputs that are capable with the system. Products, byproducts, and intermediates were all monitored in full-scan mass spectra, generating a complete view of the reaction progress. Tandem mass spectrometry experiments were conducted to verify the identity of the products formed. The amine and electrophile reactivity trends represented in the data match what is expected from theory, indicating that the system accurately models the reaction performance. The DESI results correlated well with those generated using more traditional mass spectrometry techniques like liquid chromatography-mass spectrometry, validating the data generated by the system.

Facile synthesis of 4-substituted 1,2,4,5-tetrahydro-1,4-benzodiazepin-3-ones by reductive cyclization of 2-chloro-N-(2-nitrobenzyl)acetamides

A facile and efficient method was developed for the synthesis of 1,2,4,5-tetrahydro-1,4-benzodiazepine-3-ones from 2-chloro-N-(2-nitrobenzyl)acetamides through a reductive cyclization using iron-ammonium chloride in ethanol–water in good yields. This method provides a simple approach to these benzodiazepine-3-ones which are of high value in the field of medicinal chemistry research.

Quinazolinones, Quinazolinthiones, and Quinazolinimines as Nitric Oxide Synthase Inhibitors: Synthetic Study and Biological Evaluation

The synthesis of different compounds with a quinazolinone, quinazolinthione, or quinazolinimine skeleton and their in vitro biological evaluation as inhibitors of inducible and neuronal nitric oxide synthase (iNOS and nNOS) isoforms are described. These d