911305-84-5 Usage
Chemical class
1H-Indazole, 5-bromo-3-(phenylmethyl)belongs to the indazole class of compounds.
Substitution
The compound is a substituted indazole, with a bromine atom at the 5th position and a phenylmethyl group attached at the 3rd position.
Usage
It is primarily used in organic synthesis and pharmaceutical research as a building block for the synthesis of various biologically active molecules.
Potential applications
1H-Indazole, 5-bromo-3-(phenylmethyl)has potential applications in the development of new drugs due to its ability to modulate biological pathways and interact with specific targets in the human body.
Research interest
As a result, it is of interest to researchers in the pharmaceutical and medicinal chemistry fields for its potential therapeutic applications.
Check Digit Verification of cas no
The CAS Registry Mumber 911305-84-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 9,1,1,3,0 and 5 respectively; the second part has 2 digits, 8 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 911305-84:
(8*9)+(7*1)+(6*1)+(5*3)+(4*0)+(3*5)+(2*8)+(1*4)=135
135 % 10 = 5
So 911305-84-5 is a valid CAS Registry Number.
911305-84-5Relevant academic research and scientific papers
Synthesis and SAR of indazole-pyridine based protein kinase B/Akt inhibitors
Woods, Keith W.,Fischer, John P.,Claiborne, Akiyo,Li, Tongmei,Thomas, Sheela A.,Zhu, Gui-Dong,Diebold, Robert B.,Liu, Xuesong,Shi, Yan,Klinghofer, Vered,Han, Edward K.,Guan, Ran,Magnone, Shayna R.,Johnson, Eric F.,Bouska, Jennifer J.,Olson, Amanda M.,Jong, Ron de,Oltersdorf, Tilman,Luo, Yan,Rosenberg, Saul H.,Giranda, Vincent L.,Li, Qun
, p. 6832 - 6846 (2007/10/03)
A series of heteroaryl-pyridine containing inhibitors of Akt are reported. The synthesis and structure-activity relationships are discussed, leading to the discovery of a indazole-pyridine analogue (Ki = 0.16 nM). These compounds bind in the ATP binding site, are potent, ATP competitive, and reversible inhibitors of Akt activity. No selectivity amongst the Akt isoforms is observed for this analogue, but there is good selectivity against an panel of other kinases. It is least selective for other members of the AGC family of kinases but is nonetheless 40-fold selective for Akt over PKA. The compound shows cellular activity and significantly slows tumor growth in vivo.
