91132-18-2

Upstream product

• 824940-92-3 2-(4-isopropylphenyl)-2-((trimethylsilyl)oxy)acetonitrile 
• 151-50-8 potassium cyanide 
• 122-03-2 (4-isopropylbenzaldehyde) 

Downstream Products

• 91339-24-1 2-amino-1-(4-isopropylphenyl)ethanol 
• 3866-00-0 5-(4-isopropyl-phenyl)-4,5-dihydro-oxazol-2-ylamine 
• 536-66-3 p-isopropylbenzoic acid 
• 122-03-2 (4-isopropylbenzaldehyde) 
• 66582-15-8 (4-Isopropyl-phenyl)-oxo-acetonitrile 
• 4607-63-0 4-isopropylmandelic acid 

Relevant academic research and scientific papers

Acceptorless and Base-free Dehydrogenation of Cyanohydrin with (η6-Arene)halide(Bidentate Phosphine)ruthenium(II) Complex

Ruthenium-catalyzed dehydrogenation of cyanohydrins under acceptorless and base-free conditions was demonstrated for the first time in the synthesis of acyl cyanide. As opposed to the thermodynamically preferred elimination of hydrogen cyanide, the dehydrogenation of cyanohydrins could be kinetically controlled with ruthenium (II) bidentate phosphine complexes. The effects of the arene, phosphine ligands and counter anions were investigated in regard to catalytic activity and selectivity. Selective dehydrogenation can occur via β-hydride elimination with the experimentally observed [(alkoxide)Ru] complex. (Figure presented.).

(S)-naproxen as a derivatizing agent to determine enantiomeric excess of cyanohydrins by HPLC

An easy, inexpensive and accurate method to determine enantiomeric excess of cyanohydrins is described. The method consists in derivatization of cyanohydrins with (S)-naproxen chloride and the products analyzed by HPLC. The results of enantiomeric excess so determined are similar to those obtained with [Eu(hfc)3], as a chiral shift reagent, and analysis by 1H- NMR of the cyanohydrins.

Amides for the treatment of atherosclerosis

This invention provides amide compounds as inhibitors of acyl-Coenzyme A: cholesterol O-acyltransferase (ACAT), pharmaceutical compositions containing such compounds, processes for the preparation of such compounds, and the use of such compounds as antihypercholesterolemic and/or antiatherosclerotic agents.

Enzymatic Preparation of Optically Active Cyanohydrin Acetates

A series of cyanohydrin acetates (1)-(47) of widely varying structures, potential chiral building blocks for numerous synthetic applications, has been prepared in good chemical and often high optical yields by enzymatic hydrolysis of their racemic acetates in the presence of an ester hydrolase from Pseudomonas sp.