4607-63-0

Upstream product

• 151-50-8 potassium cyanide 
• 122-03-2 (4-isopropylbenzaldehyde) 
• 98-82-8 Isopropylbenzene 
• 609-09-6 Diethyl ketomalonate 
• 51208-83-4 2-(4-isopropylphenyl)-2-oxoacetic acid 
• 91132-18-2 2-hydroxy-2-(4-isopropylphenyl)acetonitrile 
• 74-90-8 hydrogen cyanide 
• 75-25-2 Bromoform 

Downstream Products

• 105401-52-3 methyl 2-hydroxy-2-[4-(propan-2-yl)phenyl] acetate 
• 4476-28-2 (4-isopropylphenyl)acetic acid 
• 51208-83-4 2-(4-isopropylphenyl)-2-oxoacetic acid 
• 165263-45-6 DL-α-Chlor-p-cumenylessigsaeure 
• 421545-72-4 5-(4-isopropyl-phenyl)-[1,3]dioxolane-2,4-dione 
• 1206733-80-3 6-bromo-3-(4-isopropylphenyl)-4,5,7-trimethyl-1-benzofuran-2(3H)-one 

Relevant academic research and scientific papers

Chemoenzymatic Preparation of Enantiomerically Enriched (R)-(–)-Mandelic Acid Derivatives: Application in the Synthesis of the Active Agent Pemoline

The enantioselective resolution of several racemic derivatives of mandelic acid methyl ester catalyzed by lipases from Pseudomonas fluorescens (Amano AK) or Burkholderia cepacia (Amano PS-C II and Amano PS-IM) has been achieved. A gram-scale lipase-mediated kinetic resolution approach has been developed that allows the facile synthesis of the corresponding methyl (R)-(–)-mandelates with excellent enantiomeric excesses (up to >99 % ee) and reaction enantioselectivity (E values up to >200). The dopaminergic agent pemoline, used in the treatment of attention-deficit hyperactivity disorder (ADHD) and narcolepsy, was synthesized with 98 % ee in a straightforward route by condensing the prepared methyl (R)-(–)-mandelate with guanidine hydrochloride under basic conditions. The desired (R)-(+)-pemoline in optically pure form (>99 % ee) was obtained after two recrystallizations from ethanol. However, it was confirmed by chiral HPLC that optically active pemoline undergoes racemization in methanol solution.

The Synthesis of Chiral α-Aryl α-Hydroxy Carboxylic Acids via RuPHOX-Ru Catalyzed Asymmetric Hydrogenation

A ruthenocenyl phosphino-oxazoline-ruthenium complex (RuPHOX?Ru) catalyzed asymmetric hydrogenation of α-aryl keto acids has been successfully developed, affording the corresponding chiral α-aryl α-hydroxy carboxylic acids in high yields and with up to 97% ee. The reaction could be performed on a gram scale with a relatively low catalyst loading (up to 5000 S/C) and the resulting products can be transformed to several chiral building blocks, biologically active compounds and chiral drugs. (Figure presented.).

CANNABINOID RECEPTOR MODULATOR

A cannabinoid receptor modulator containing a compound represented by Formula (I0) wherein, X is an oxygen atom, etc., R° is an optionally substituted acylamino group, ring A0 is a benzene ring which may further have a substituent in addition to R°, and ring B is an optionally substituted 5-membered heterocycle, or a salt thereof or a prodrug thereof.

Amides for the treatment of atherosclerosis

This invention provides amide compounds as inhibitors of acyl-Coenzyme A: cholesterol O-acyltransferase (ACAT), pharmaceutical compositions containing such compounds, processes for the preparation of such compounds, and the use of such compounds as antihypercholesterolemic and/or antiatherosclerotic agents.