91132-80-8Relevant academic research and scientific papers
Intramolecular functionalization of C(sp3)–H bonds adjacent to an amide nitrogen atom: Metal-free synthesis of 2-hydroxy-benzoxazinone derivatives
Gao, Biao,Chen, Kaili,Bi, Xiaoling,Wang, Jinxin
, p. 7005 - 7010 (2017)
An intramolecular C(sp3)–H bond functionalization adjacent to an amide nitrogen atom was successfully developed for synthesis of 2-hydroxybenzoxazinone derivatives under environment-friendly conditions. The method featured no metal catalyst, broad substrate scopes and high yields. Besides, a radical mechanism was proposed in the reaction process. Additionally, most of target compounds exhibited potent anti-proliferative activities against MCF-7 and Hela cells.
N-phosphinyl phosphoramide-A Chiral Bronsted acid motif for the direct asymmetric N,O-acetalization of aldehydes
Vellalath, Sreekumar,Coric, Ilija,List, Benjamin
supporting information; experimental part, p. 9749 - 9752 (2011/02/23)
Fine-tuning the sites: The readily accessible N-phosphinyl phosphoramide 1 proved to be highly efficient and enantioselective in catalyzing the title reaction. The synthetic utility of this methodology was demonstrated with the first catalytic asymmetric synthesis of the analgesic pharmaceutical (R)-chlorothenoxazine (see scheme). Copyright
