911381-66-3

Upstream product

• 911381-65-2 (-)-[S_S,N(1S),3S,7R]-N-{1-[tert-butyl(dimethyl)silanyloxymethyl]-2-methyl-propyl}-2-(3-hydroxy-3-{8-[1-(p-tolyl-sulfonimidoyl)meth-(Z)-ylidene]-1,4-dioxa-spiro[4.5]dec-7-yl}propyl)isoindole-1,3-dione 
• 4746-97-8 cyclohexanedione monoethylene ketal 
• 911381-59-4 (+)-[S_S,N(1S)]-N-{1-[tert-butyl(dimethyl)silanyloxymethyl]-2-methyl-propyl}-4-(p-tolyl-sulfonimidomethyl)-1,4-dioxa-spiro[4.5]dec-7-ene 

Relevant academic research and scientific papers

Synthesis of highly functionalized azabicycles via 2-alkenyl sulfoximines

Functionalized cycloalkanones have been converted into enantiomerically pure endocyclic 2-alkenyl sulfoximines. Titanated derivatives thereof undergo highly diastereoselective γ-hydroxyalkylation reactions with various amino aldehydes yielding isomerically pure vinyl sulfoximines, which can be cyclized by N-deprotection. The resulting heterobicyclic systems are expected to be interesting scaffolds for the synthesis of topological mimetics of peptides. Georg Thieme Verlag Stuttgart.