911381-71-0Relevant articles and documents
Synthesis of highly functionalized azabicycles via 2-alkenyl sulfoximines
Reggelin, Michael,Kuehl, Jochen,Kaiser, Jan Philipp,Buehle, Philipp
, p. 2224 - 2232 (2006)
Functionalized cycloalkanones have been converted into enantiomerically pure endocyclic 2-alkenyl sulfoximines. Titanated derivatives thereof undergo highly diastereoselective γ-hydroxyalkylation reactions with various amino aldehydes yielding isomerically pure vinyl sulfoximines, which can be cyclized by N-deprotection. The resulting heterobicyclic systems are expected to be interesting scaffolds for the synthesis of topological mimetics of peptides. Georg Thieme Verlag Stuttgart.