911435-00-2

Upstream product

• 89415-43-0 (4-aminophenyl)boronic acid 
• 96232-68-7 4,5-Dibromo-3-methoxycarbonylmethoxy-thiophene-2-carboxylic acid methyl ester 

Downstream Products

• 911435-16-0 4-bromo-3-methoxycarbonylmethoxy-5-[4-(4-trifluoromethyl-benzenesulfonylamino)-phenyl]-thiophene-2-carboxylic acid methyl ester 
• 911435-04-6 5-(4-acetylamino-phenyl)-4-bromo-3-methoxycarbonylmethoxy-thiophene-2-carboxylic acid methyl ester 
• 911435-20-6 4-bromo-5-(4-methoxycarbonylamino-phenyl)-3-methoxycarbonylmethoxy-thiophene-2-carboxylic acid methyl ester 
• 864132-92-3 4-bromo-3-carboxymethoxy-5-(4-methanesulfonylamino-phenyl)-thiophene-2-carboxylic acid 
• 911435-22-8 4-bromo-5-[4-(3-isopropyl-ureido)-phenyl]-3-methoxycarbonylmethoxy-thiophene-2-carboxylic acid methyl ester 
• 911435-14-8 4-bromo-5-(4-methanesulfonylamino-phenyl)-3-methoxycarbonylmethoxy-thiophene-2-carboxylic acid methyl ester 
• 911435-10-4 5-(4-benzoylamino-phenyl)-4-bromo-3-methoxycarbonylmethoxy-thiophene-2-carboxylic acid methyl ester 
• 911435-06-8 4-bromo-5-{4-[(furan-2-carbonyl)-amino]-phenyl}-3-methoxycarbonylmethoxy-thiophene-2-carboxylic acid methyl ester 
• 911435-08-0 4-bromo-3-methoxycarbonylmethoxy-5-{4-[(pyridine-3-carbonyl)-amino]-phenyl}-thiophene-2-carboxylic acid methyl ester 

Relevant academic research and scientific papers

Monocyclic thiophenes as protein tyrosine phosphatase 1B inhibitors: Capturing interactions with Asp48

A series of monocyclic thiophenes was designed and synthesized as PTP1B inhibitors. Guided by X-ray co-crystal structural information and computational modeling, rational design led to key interactions with Asp48 and improved inhibitory potency against PT