91145-92-5Relevant academic research and scientific papers
NUCLEOPHILIC SUBSTITUTION OF HALOGEN ATOMS IN gem-DICHLOROCYCLOPROPANES ACTIVATED BY ELECTRON-WITHDRAWING SUBSTITUENTS
Kulinkovich, O. G.,Tishchenko, I. G.,Romashin, Yu. N.
, p. 213 - 216 (2007/10/02)
The reactions of the methyl ester, N,N-dimethylamide, and nitrile of gem-dichlorocyclopropanecarboxylic acid with sodium methoxide and ethoxide take place with opening of the three-membered ring and lead to the correponding derivatives of succinic acid.Methyl and ethyl 3-formyl-2-methylpropionate were obtained from 2,2-dichloro-1-formyl-3-methylcyclopropane under analogous conditions.The reaction of sodium thiophenolate with the functionally substituted gem-dichlorocyclopropanes takes place with retention of the three-membered ring and the formation of the corresponding substituted diphenyl thioacetals of cyclopropanone.
