91147-75-0

Basic information

• Product Name: A-BROMO-4-NITROACETOPHENONE HEXAMINE
• Synonyms: A-BROMO-4-NITROACETOPHENONE HEXAMINE;2-Bromo-1-(4-nitrophenyl)ethanone compound with 1,3,5,7-tetraazatricyclo[3.3.1.1./3.7]decane;α-Bromo-4-nitroacetophenone hexamine
• CAS NO: 91147-75-0
• Molecular Formula: C₆H₁₂N₄*C₈H₆BrNO₃
• Molecular Weight: 384.22842
• Mol File: 91147-75-0.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: A-BROMO-4-NITROACETOPHENONE HEXAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: A-BROMO-4-NITROACETOPHENONE HEXAMINE(91147-75-0)
• EPA Substance Registry System: A-BROMO-4-NITROACETOPHENONE HEXAMINE(91147-75-0)

Safety Data

• Hazardous Substances Data: 91147-75-0(Hazardous Substances Data)

Upstream product

• 100-97-0 hexamethylenetetramine 
• 99-81-0 4-Nitrophenacyl bromide 

Downstream Products

• 1456532-32-3 2-amino-1-(4-nitro) acetophenone thiosemicarbazone hemisuccinate amide 
• 5425-81-0 2-amino-1-(4-nitrophenyl)ethanone hydrochloride 
• 1456532-36-7 2-amino-1-(4-nitro)acetophenone thiosemicarbazone 

Relevant articles and documents

Design, synthesis and biological evaluation of new aryl thiosemicarbazone as antichagasic candidates

The present work reports on the synthesis, biological assaying and docking studies of a series of 12 aryl thiosemicarbazones, which were planned to act over two main enzymes, cruzain and trypanothione reductase. These enzymes are used as targets of trypanocidal activity in Chagas disease control with a minimal mutagenic profile. Three p-nitroaromatic thiosemicarbazones showed high activity against Trypanosoma cruzi in in vitro assays (IC50 57 μM), and no mutagenic profile was observed in micronucleous tests. Although the in vitro inhibition test showed that 10-μM doses of eight compounds inhibited cruzain activity, no correlation was found between cruzain inhibition and trypanocidal activity.