911491-47-9Relevant articles and documents
N-(4-Fluorobenzyl)-3-hydroxy-9,9-dimethyl-4-oxo-6,7,8,9-tetrahydro-4H-pyrazino[1,2-a]pyrimidine-2-carboxamides a novel class of potent HIV-1 integrase inhibitors
Petrocchi, Alessia,Jones, Philip,Rowley, Michael,Fiore, Fabrizio,Summa, Vincenzo
scheme or table, p. 4245 - 4249 (2010/04/02)
A novel class of tetrahydro-pyrazinopyrimidine-2-carboxamides have been identified as HIV-1 integrase inhibitors. Optimization of the initial lead culminated in the discovery of a series of compounds with high potency on the enzyme and an antiviral cell-b