118994-86-8

Basic information

• Product Name: 5-OXAZOLECARBOXALDEHYDE
• Synonyms: 5-OXAZOLECARBOXALDEHYDE;OXAZOLE-5-CARBALDEHYDE;5-Oxazolecarboxaldehyde (9CI);1,3-oxazole-5-carbaldehyde;tert-butyl 1-aMino-8-azaspiro[4.5]decane-8-carboxylate;oxazole-5-carboxaldehyde;5-Formyloxazole;1,3-Oxazole-5-carboxaldehyde
• CAS NO: 118994-86-8
• Molecular Formula: C₄H₃NO₂
• Molecular Weight: 97.07
• Product Categories: ALDEHYDE
• Mol File: 118994-86-8.mol
• Article Data: 12

Chemical Properties

• Melting Point: 30-32℃
• Boiling Point: 184.7 °C at 760 mmHg
• Flash Point: 65.504 °C
• Appearance: /
• Density: 1.259 g/cm³
• Vapor Pressure: 0.723mmHg at 25°C
• Refractive Index: 1.519
• PKA: -1.09±0.10(Predicted)
• CAS DataBase Reference: 5-OXAZOLECARBOXALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-OXAZOLECARBOXALDEHYDE(118994-86-8)
• EPA Substance Registry System: 5-OXAZOLECARBOXALDEHYDE(118994-86-8)

Safety Data

• Hazard Codes: Xn
• Statements: 22-36-43
• Safety Statements: 26-36/37
• Hazardous Substances Data: 118994-86-8(Hazardous Substances Data)

Usage

General Description

5-Oxazolecarboxaldehyde is a chemical compound with the molecular formula C4H3NO2. It is a heterocyclic organic compound containing a five-membered oxazole ring with a carboxaldehyde functional group. It is commonly used in organic synthesis as a building block for the preparation of various pharmaceuticals and agrochemicals. 5-Oxazolecarboxaldehyde exhibits a variety of chemical reactions, including oxidation, reduction, and condensation, making it a versatile intermediate in the production of complex organic molecules. It is also known for its potential use in the synthesis of pyrazoles, benzothiazoles, and other nitrogen-containing heterocycles. However, it is important to handle 5-Oxazolecarboxaldehyde with care as it is a flammable liquid and may cause irritation to the skin, eyes, and respiratory system.

InChI:InChI=1/C4H3NO2/c6-2-4-1-5-3-7-4/h1-3H

Upstream product

• 118994-89-1 oxazol-5-yl-carboxylic acid ethyl ester 
• 75-09-2 dichloromethane 
• 7732-18-5 water 
• 104336-01-8 5-((diethoxy)methyl)oxazole 
• 127232-41-1 1,3-oxazol-5-ylmethanol 

Downstream Products

• 127232-41-1 1,3-oxazol-5-ylmethanol 
• 1453853-38-7 (4-chloro-3-fluorophenyl)(oxazol-5-yl)methanol 
• 911491-47-9 C₂₁H₂₂FN₅O₄ 
• 1029800-20-1 (2RS,4R)-2-(2-fluorophenyl)-thiazolidine-4-carboxylic acid 
• 321434-76-8 (4R)-N-[(2-chloro-6-methylphenyl)methyl]-3-[(2S,4S)-5-[((3S,4S)-3,4-dihydro-3-hydroxy-2H-1-benzopyran-4-yl)amino]-2-hydroxy-4-(5-oxazolylmethyl)-1,5-dioxopentyl]-5,5-dimethyl-4-thiazolidinecarboxamide 
• 214550-89-7 [4-(tert-Butyl-diphenyl-silanyloxymethyl)-oxazol-2-yl]-oxazol-5-yl-methanol 

Relevant articles and documents

Vinylnaphthalene-bearing hexaoxazole as a fluorescence turn-on type G-quadruplex ligand

Oxazole-type fluorophores show an increase of fluorescence intensity upon interaction with nucleic acids, and therefore can be used as tools for nucleic acid-sensing and fluorescence imaging. Here, we developed a novel stilbene-type fluorophore, MO-VN (1), consisting of a mono oxazole bearing a vinyl naphthalene moiety. This compound (1) was embedded in a trioxazole2and a cyclic hexaoxazole3a. The fluorescence properties of1,2, and3awere evaluated in the presence of various nucleic acid sequences. Compound3showed significant fluorescent enhancement upon interacting with G-quadruplex (G4) structure, which plays critical roles in various biological phenomena. Further structural development focusing on the vinyl naphthalene moiety of3aafforded a turn-on type G4 ligand3ethat shows G4-specific fluorescence. Measurement of the fluorescence of3eduring titration of a telomeric DNA, telo24, with its C-rich complementary sequence, which unwinds the G4 structure, allowed us to monitor the dynamics of G4.

Photochemical approach to functionalized benzobicyclo[3.2.1]octene structures via fused oxazoline derivatives from 4-and 5-(o-vinylstyryl) oxazoles

Novel cis/trans-4- and cis/trans -5-(2-vinylstyryl)oxazoles have been synthesized by Wittig reactions from the diphosphonium salt of α,α'- o -xylene dibromide, formaldehyde and 4- and 5-oxazolecarbaldehydes, respectively. In contrast, trans -5-(2-vinylsty

Total synthesis of the potent antifungal agents bengazole C and E

The bengazoles are marine natural products with unique structure, containing two oxazole rings flanking a single carbon. They show very potent antifungal activity. The total syntheses of bengazole C and E are described following a convergent route which involves diastereoselective cycloaddition of an appropriately substituted nitrile oxide with a butane-1,2-diacetal-protected alkenediol as the key step.