91154-09-5Relevant academic research and scientific papers
Weak arene C-h×××o hydrogen bonding in palladium-catalyzed arylation and vinylation of lactones
Huang, Zhiyan,Chen, Zuliang,Lim, Li Hui,Quang, Gia Chuong Phan,Hirao, Hajime,Zhou, Jianrong
supporting information, p. 5807 - 5812 (2013/07/05)
Weak force in action: In the title reaction, the palladium catalyst (see figure, left) uses weak CH×××O hydrogen bonding to control the absolute configuration of the new stereocenter. A similar palladium catalyst (right) used conventional NH×××O hydrogen bonding to guide stereoselection. Copyright
Enantioselective acylation of silyl ketene acetals through fluoride anion-binding catalysis
Birrell, James A.,Desrosiers, Jean-Nicolas,Jacobsen, Eric N.
supporting information; experimental part, p. 13872 - 13875 (2011/10/09)
A highly enantioselective acylation of silyl ketene acetals with acyl fluorides has been developed to generate useful α,α-disubstituted butyrolactone products. This transformation is promoted by a new thiourea catalyst and 4-pyrrolidinopyridine and represents the first example of enantioselective thiourea anion-binding catalysis with fluoride.
GEMINALLY SUBSTITUTED CYCLIC ETHER CARBOXYLIC ACIDS, DERIVATIVES, THEREOF, COMOPOSITIONS CONTAINING SAME AND METHOD OF USE
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, (2008/06/13)
Geminally-substituted cyclic ether carboxylic acids or derivatives thereof are provided which have the structure STR1 wherein Z is aryl, which may be optionally substituted with one or more of the following groups: halo, lower alkyl, lower alkoxy, hydroxy, lower alkylamino, phenyl or carbo-lower alkoxy STR2 R is COOH, COO alkali metal, coo lower alkyl, STR3 R 1 is lower alkyl or aryl; n is 1 or 2;p is 2 to 5; andq is 1 to 4.These compounds are cardiovascular agents which exhibit thromboxane antagonist activity and thus are useful in the treatment of thrombotic disease.
A NEW SYNTHESIS OF trans-2-SUBSTITUTED-2-BUTENE-1,4-DIOLS FROM 2-BUTYNE-1,4-DIOL VIA NUCLEOPHILIC ADDITION OF GRIGNARD REAGENTS
Ishino, Yoshio,Wakamoto, Kohji,Hirashima, Tsuneaki
, p. 765 - 768 (2007/10/02)
trans-2-Substituted-2-butene-1,4-diols were readily obtained by reactions of 2-butyne-1,4-diol with Grignard reagents in good yields.
