911641-01-5

Upstream product

• 875551-59-0 tert-butyl N-[[(2S)-morpholin-2-yl]methyl]carbamate 
• 875551-47-6 1,1-dimethylethyl {[(2R)-4-(phenylmethyl)-2-morpholinyl]methyl}carbamate 
• 911641-00-4 1,1-dimethylethyl ({(2R)-4-[(2-cyanophenyl)sulfonyl]-2-morpholinyl}methyl)carbamate 

Downstream Products

• 911641-02-6 N₁-({(2R)-4-[(2-cyanophenyl)sulfonyl]-2-morpholinyl}methyl)-N₂-{[(1,1-dimethylethyl)oxy]carbonyl}-L-leucinamide 

Relevant academic research and scientific papers

NOVEL COMPOUNDS

This invention relates to novel compounds useful in the treatment of diseases associated with TRPV4 channel receptor. More specifically, this invention relates to certain substituted morpholines and piperidines, according to Formula I wherein: X is O or CH2; R1 is optionally substituted C3-7cycloalkyl, C3-6cycloalkyl-C0-6alkyl, optionally substituted C4-7cycloalkenyl, optionally substituted Het-C0-7alkyl, optionally substituted Het-C0-7alkenyl, optionally substituted aryl, optionally substituted heterocycloalkyl, or optionally substituted heteroaryl- R2 is H, branched or optionally substituted C1-6alkyl, C3-6cycloalkyl-C0-6alkyl, Ar-C0-6alkyl, or Het-C0-6alkyl; and R3 is optionally substituted heterocycloalkyl, optionally substituted aryl, or optionally substituted heteroaryl; or pharmaceutically acceptable salts, hydrates, solvates and physiologically functional derivatives thereof.