2-{[(2R)-2-(aminomethyl)-4-morpholinyl]sulfonyl}benzonitrile hydrochloride

Base Information

• Chemical Name: 2-{[(2R)-2-(aminomethyl)-4-morpholinyl]sulfonyl}benzonitrile hydrochloride
• CAS No.: 911641-01-5
• Molecular Formula: C₁₂H₁₅N₃O₃S*ClH
• Molecular Weight: 317.796
• Mol file: 911641-01-5.mol

Synonyms:2-{[(2R)-2-(aminomethyl)-4-morpholinyl]sulfonyl}benzonitrile hydrochloride

Chemical Property of 2-{[(2R)-2-(aminomethyl)-4-morpholinyl]sulfonyl}benzonitrile hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-{[(2R)-2-(aminomethyl)-4-morpholinyl]sulfonyl}benzonitrile hydrochloride

There total 3 articles about 2-{[(2R)-2-(aminomethyl)-4-morpholinyl]sulfonyl}benzonitrile hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1,1-dimethylethyl ({(2R)-4-[(2-cyanophenyl)sulfonyl]-2-morpholinyl}methyl)carbamate (911641-00-4) → 2-{[(2R)-2-(aminomethyl)-4-morpholinyl]sulfonyl}benzonitrile hydrochloride (911641-01-5)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; ethyl acetate; for 48h;

Reference yield:

1,1-dimethylethyl {[(2R)-4-(phenylmethyl)-2-morpholinyl]methyl}carbamate (875551-47-6) → 2-{[(2R)-2-(aminomethyl)-4-morpholinyl]sulfonyl}benzonitrile hydrochloride (911641-01-5)

Guidance literature:

Multi-step reaction with 3 steps

1: hydrogen / palladium 10% on activated carbon / methanol / 43 h / 760.05 Torr

2: triethylamine / dichloromethane / 16 h / 0 - 20 °C

3: hydrogenchloride / 1,4-dioxane; ethyl acetate / 48 h

With hydrogenchloride; hydrogen; triethylamine; palladium 10% on activated carbon; In 1,4-dioxane; methanol; dichloromethane; ethyl acetate;

Reference yield:

tert-butyl N-[[(2S)-morpholin-2-yl]methyl]carbamate (875551-59-0) → 2-{[(2R)-2-(aminomethyl)-4-morpholinyl]sulfonyl}benzonitrile hydrochloride (911641-01-5)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 16 h / 0 - 20 °C

2: hydrogenchloride / 1,4-dioxane; ethyl acetate / 48 h

With hydrogenchloride; triethylamine; In 1,4-dioxane; dichloromethane; ethyl acetate;

upstream raw materials:

1,1-dimethylethyl ({(2R)-4-[(2-cyanophenyl)sulfonyl]-2-morpholinyl}methyl)carbamate

tert-butyl N-[[(2S)-morpholin-2-yl]methyl]carbamate

1,1-dimethylethyl {[(2R)-4-(phenylmethyl)-2-morpholinyl]methyl}carbamate

Downstream raw materials:

N₁-({(2R)-4-[(2-cyanophenyl)sulfonyl]-2-morpholinyl}methyl)-N₂-{[(1,1-dimethylethyl)oxy]carbonyl}-L-leucinamide