911645-49-3Relevant academic research and scientific papers
Oxidation of biotin during oligonucleotide synthesis
Upadhya, Krishna,Khattak, Iqbal K.,Mullah, Bashar
, p. 919 - 922 (2007/10/03)
A new "polystyrene biotin support" has been synthesized for the solid support synthesis of the 3′-biotinylated oligonucleotides. Several oligos were synthesized and were analyzed by the HPLC and Mass Spec. Oligo analysis revealed that the biotin gets oxidized to "biotin sulfoxide" during the synthesis. Copyright Taylor & Francis, Inc.
