911694-22-9

Upstream product

• 857900-11-9 N-{(1S)-1-[(methoxy)methyl]-2-methylpropyl}-N-{(1E)-phenyl[(2S)-2-phenyl-3,4-dihydropyridin-1(2H)-yl]methylene}amine 
• 591-50-4 iodobenzene 
• 3262-89-3 triphenylboroxine 
• 911694-13-8 N-[(1E)-[(2S)-5-iodo-2-phenyl-3,4-dihydropyridin-1(2H)-yl](phenyl)methylidene]-N-[(1S)-1-(methoxymethyl)-2-methylpropyl]amine 

Downstream Products

• 911694-28-5 N-[(1E)-[(2S,5R)-2,5-diphenylpiperidin-1-yl](phenyl)methylene]-N-[(1S)-1-(methoxymethyl)-2-methylpropyl]amine 
• 1071527-76-8 (2R,3S,6S)-2-methoxy-1-((E)-((S)-1-methoxy-3-methylbutan-2-ylimino)(phenyl)methyl)-3,6-diphenylpiperidin-3-ol 

Relevant academic research and scientific papers

Highly regioselective intermolecular arylation of 1,2,3,4- tetrahydropyridines

(Equation Presented) Using a catalytic amount of PdCl2(dppf) ·CH2Cl2 in combination with Ag3PO 4 and NaOAc, a range of arylated 1,2,3,4-tetrahydropyridines are synthesized in good yields and with complete selectivity at the β-position. The reaction is compatible with a variety of electron-donating and electron-withdrawing aryl iodides as well as with heteroaryl iodides. The application of these tetrahydropyridines toward the synthesis of polysubstituted piperidines is also demonstrated.

New methodology toward chiral, non-racemic 2,5-cis-substituted piperidines via Suzuki cross-coupling

1,2,3,4-Tetrahydropyridines were halogenated upon treatment with iodine to obtain the desired cross-coupling precursors. Diastereoselective hydrogenation of Suzuki cross-coupling adducts allowed the facile asymmetric synthesis of 2,5-cis-substituted piper