911694-28-5Relevant academic research and scientific papers
Highly regioselective intermolecular arylation of 1,2,3,4- tetrahydropyridines
Pelletier, Guillaume,Larivee, Alexandre,Charette, Andre B.
supporting information; experimental part, p. 4791 - 4794 (2009/05/31)
(Equation Presented) Using a catalytic amount of PdCl2(dppf) ·CH2Cl2 in combination with Ag3PO 4 and NaOAc, a range of arylated 1,2,3,4-tetrahydropyridines are synthesized in good yields and with complete selectivity at the β-position. The reaction is compatible with a variety of electron-donating and electron-withdrawing aryl iodides as well as with heteroaryl iodides. The application of these tetrahydropyridines toward the synthesis of polysubstituted piperidines is also demonstrated.
