911707-35-2

Upstream product

• 911707-37-4 (3R,4R,6S)-6-hydroxymethyl-4-(4-hydroxy-phenyl)-1-(toluene-4-sulfonyl)-piperidin-3-ol 
• 67-56-1 methanol 
• 911707-36-3 trifluoro-methanesulfonic acid 4-[(2S,4R,5R)-5-hydroxy-2-hydroxymethyl-1-(toluene-4-sulfonyl)-piperidin-4-yl]-phenyl ester 
• 201230-82-2 carbon monoxide 

Downstream Products

• 911707-34-1 4-[(2S,4R,5R)-5-Hydroxy-1-(toluene-4-sulfonyl)-2-triiso-propylsilanyloxymethyl-piperidin-4-yl]-benzoic acid methyl ester 

Relevant academic research and scientific papers

Substituted piperidines as inhibitors of beta-secretase, cathepsin D, plasmepsin II and/or HIV protease

Use of compounds of the general formula (I) or (II) and pharmaceutically acceptable salt thereof, in which R, R1, R2, R3, R4, Q, W, X and Z, n and m have the definitions illustrated in detail in the description,

Organic compounds

The present invention relates to substituted piperidines of the general formula (I), where R1, R2, R3, R4, R5, Q and X have the definitions elucidated in more detail in the description, to a process for their preparation and to the use of these compounds as medicines, in particular as renin inhibitors. Moreover, the enzymatic substrate portion of the compound is simultaneously a substrate for a membrane transporter.

NITRATE ESTERS OF PIPERIDINES

The application relates to novel nitrate ester derivatives of substituted piperidines of the general formula (I), wherein R1, R2, R3, X, Y and Z0, and m, n, p and q have the meanings explained in more detail in

SUBSTITUTED PIPERIDINES

SP-P2140 ATE - 132 - Abstract Novel substituted piperidines of the general formula (I) and (II) with the substituent definitions as explained in detail in the description are described. The compounds are suitable in particular as renin inhibitors and are