91177-57-0

Basic information

• Product Name: BOC-D-METHIONINOL
• Synonyms: BOC-(R)-2-AMINO-4-METHYLTHIO-1-BUTANOL;BOC-D-MET-OL;BOC-D-METHIONINOL;N-ALPHA-T-BOC-D-METHIONINOL;N-BOC-D-METHIONINOL;N-T-BUTOXYCARBONYL-D-METHIONINOL;NALPHA-tert-Butoxycarbonyl-D-methioninol;(R)-2-t-Butyloxycarbonyl-amino-4-methylthio-1-butanol, N-alpha-t-Butyloxycarbonyl-D-methioninol
• CAS NO: 91177-57-0
• Molecular Formula: C₁₀H₂₁NO₃S
• Molecular Weight: 235.34
• Product Categories: Amino Acids
• Mol File: 91177-57-0.mol

Chemical Properties

• Appearance: Colorless crystalline
• Storage Temp.: Store at 0°C
• CAS DataBase Reference: BOC-D-METHIONINOL(CAS DataBase Reference)
• NIST Chemistry Reference: BOC-D-METHIONINOL(91177-57-0)
• EPA Substance Registry System: BOC-D-METHIONINOL(91177-57-0)

Safety Data

• Hazardous Substances Data: 91177-57-0(Hazardous Substances Data)

Usage

Chemical Properties

White powder

Upstream product

• 5241-66-7 (R)-N-(tert-butoxycarbonyl)methionine 
• 348-67-4 D-methionine 
• 502-83-0 (R)-2-amino-4-methylthio-1-butanol 
• 24424-99-5 di-tert-butyl dicarbonate 
• 34619-03-9 tert-butyldicarbonate 
• 2488-15-5 N-t-butoxycarbonyl-D-methionine 
• 33900-24-2 (R)-2-tert-Butoxycarbonylamino-4-methylsulfanyl-butyric acid methyl ester 

Downstream Products

• 300363-41-1 (+)-1,1-dimethylethyl [(1R)-1-({[(1,1-dimethylethyl)(diphenyl)silyl]oxy}methyl)prop-2-en-1-yl]carbamate 
• 89985-86-4 (R)-2-(N-tert-butoxycarbonylamino)-3-buten-1-ol 
• 91103-44-5 (S)-2-(tert-Butoxycarbonyl-{(R)-2-[tert-butoxycarbonyl-((R)-2-tert-butoxycarbonylamino-3-hydroxy-propyl)-amino]-3-hydroxy-propyl}-amino)-succinic acid dibenzyl ester 
• 91103-43-4 (S)-2-{(R)-2-[tert-Butoxycarbonyl-((R)-2-tert-butoxycarbonylamino-3-hydroxy-propyl)-amino]-3-hydroxy-propylamino}-succinic acid dibenzyl ester 
• 91103-39-8 3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (R)-4-methylsulfanyl-2-(3,3,3-trifluoro-2-methoxy-2-phenyl-propionylamino)-butyl ester 
• 91103-36-5 N-tert.-butyloxycarbonyl-L-serinal 
• 502-83-0 (R)-2-amino-4-methylthio-1-butanol 

Relevant articles and documents

Design, synthesis and biological evaluation of isoxazole-based CK1 inhibitors modified with chiral pyrrolidine scaffolds

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In the present study, nitromethylene neonicotinoid derivatives possessing substituents that contain a sulfur atom, oxygen atom or aromatic ring at position 5 on the imidazolidine ring were synthesized to evaluate their affinity for the nicotinic acetylcholine receptor (nAChR) and their insecticidal activity against adult female houseflies. Comparing the receptor affinity of the alkylated derivative with the receptor affinity of compounds possessing either ether or thioether groups revealed that conversion of the carbon atom to a sulfur atom did not influence the receptor affinity, whereas conversion to an oxygen atom was disadvantageous for the receptor affinity. The receptor affinity of compounds possessing a benzyl or phenyl group was lower than that of the unsubstituted compound. Analysis of the three-dimensional quantitative structure-activity relationship using comparative molecular field analysis demonstrated that steric hindrance of the receptor should exist around the C3 of an n-butyl group attached at position 5 on the imidazolidine ring. A docking study of the nAChR-ligand model suggested that the ligand-binding region expands as the length of the substituent increases by brushing against the amino acids that form the binding region. The insecticidal activity of the compounds was positively correlated with the receptor affinity by considering log P and the number of heteroatoms, including sulfur and oxygen atoms, in the substituents, suggesting that the insecticidal activity is influenced by the receptor affinity, hydrophobicity, and metabolic stability of the compounds.

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