911834-92-9

Upstream product

• 873195-64-3 (E)-(5S,6S)-5,6-Bis-(tert-butyl-dimethyl-silanyloxy)-octa-2,7-dienal 
• 911834-94-1 (Z)-(5S,6S)-5,6-Bis-(tert-butyl-dimethyl-silanyloxy)-octa-3,7-dienal 
• 695-12-5 vinylcyclohexane 
• 1049737-05-4 C₂₆H₃₈O₇ 
• 911834-91-8 (3Z,9E)-(1R,7S,11S,15S,17R)-7-((E)-(S)-3-Cyclohexyl-1-hydroxy-allyl)-11-hydroxy-15-methyl-13-methylene-6,21-dioxa-bicyclo[15.3.1]henicosa-3,9,19-trien-5-one 
• 438222-46-9 (R)-3-Methyl-4-((R)-4-oxo-3,4-dihydro-2H-pyran-2-yl)-butyric acid methyl ester 
• 207123-21-5 (S,S)-2,2-dimethyl-4-[(tert-butyldimethylsilyloxy)methyl]-5-vinyl-1,3-dioxolane 
• 911834-88-3 (E)-(1R,7S,11S,15S,17R)-7-((E)-(S)-3-Cyclohexyl-1-hydroxy-allyl)-11-methoxymethoxy-15-methyl-13-methylene-6,21-dioxa-bicyclo[15.3.1]henicosa-9,19-dien-3-yn-5-one 
• 911834-96-3 (3Z,9E)-(1R,7S,11S,15S,17R)-7-((E)-(S)-3-Cyclohexyl-1-hydroxy-allyl)-11-methoxymethoxy-15-methyl-13-methylene-6,21-dioxa-bicyclo[15.3.1]henicosa-3,9,19-trien-5-one 
• 911834-87-2 4-[(2R,6R)-6-((E)-(2S,6S,10S,11S)-10,11-Dihydroxy-6-methoxymethoxy-2-methyl-4-methylene-trideca-7,12-dienyl)-5,6-dihydro-2H-pyran-2-yl]-but-2-ynoic acid 
• 911834-80-5 (E)-(1R,7S,11S,15S,17R)-7-((S)-1-Hydroxy-allyl)-11-methoxymethoxy-15-methyl-13-methylene-6,21-dioxa-bicyclo[15.3.1]henicosa-9,19-dien-3-yn-5-one 
• 911834-86-1 (E)-(3S,4S,8S,12S)-8-Methoxymethoxy-12-methyl-10-methylene-13-((2R,6R)-6-prop-2-ynyl-3,6-dihydro-2H-pyran-2-yl)-trideca-1,6-diene-3,4-diol 
• 911834-83-8 (Z)-(3S,4S)-3,4,8-Tris-(tert-butyl-dimethyl-silanyloxy)-octa-1,5-diene 
• 911834-81-6 (2R,6R)-2-((S)-2-Methyl-4-trimethylsilanylmethyl-pent-4-enyl)-6-(3-trimethylsilanyl-prop-2-ynyl)-3,6-dihydro-2H-pyran 

Downstream Products

• 1049737-16-7 C₃₀H₄₂O₆ 
• 1049737-12-3 C₃₁H₄₀O₆ 

Relevant academic research and scientific papers

LAULIMALIDE AND LAULIMALIDE ANALOGS

Novel laulimalide analogs, methods for the treatment of proliferative disease and processes for the synthesis of laulimalide and novel laulimalide analogs are described.

Pharmacophore mapping in the laulimalide series: Total synthesis of a vinylogue for a late-stage metathesis diversification strategy

An efficient synthesis of the macrocyclic core of laulimalide with a pendant vinyl group at C20 is described, allowing for late-stage introduction of various side chains through a selective and efficient cross metathesis diversification step. Representati