911834-96-3

Upstream product

• 438222-46-9 (R)-3-Methyl-4-((R)-4-oxo-3,4-dihydro-2H-pyran-2-yl)-butyric acid methyl ester 
• 207123-21-5 (S,S)-2,2-dimethyl-4-[(tert-butyldimethylsilyloxy)methyl]-5-vinyl-1,3-dioxolane 
• 911834-95-2 (2R,6R)-2-[(E)-(2S,6S,10S,11S)-10,11-Bis-(tert-butyl-dimethyl-silanyloxy)-6-methoxymethoxy-2-methyl-4-methylene-trideca-7,12-dienyl]-6-(3-trimethylsilanyl-prop-2-ynyl)-3,6-dihydro-2H-pyran 
• 911834-87-2 4-[(2R,6R)-6-((E)-(2S,6S,10S,11S)-10,11-Dihydroxy-6-methoxymethoxy-2-methyl-4-methylene-trideca-7,12-dienyl)-5,6-dihydro-2H-pyran-2-yl]-but-2-ynoic acid 
• 911834-80-5 (E)-(1R,7S,11S,15S,17R)-7-((S)-1-Hydroxy-allyl)-11-methoxymethoxy-15-methyl-13-methylene-6,21-dioxa-bicyclo[15.3.1]henicosa-9,19-dien-3-yn-5-one 
• 911834-86-1 (E)-(3S,4S,8S,12S)-8-Methoxymethoxy-12-methyl-10-methylene-13-((2R,6R)-6-prop-2-ynyl-3,6-dihydro-2H-pyran-2-yl)-trideca-1,6-diene-3,4-diol 
• 911834-83-8 (Z)-(3S,4S)-3,4,8-Tris-(tert-butyl-dimethyl-silanyloxy)-octa-1,5-diene 
• 911834-81-6 (2R,6R)-2-((S)-2-Methyl-4-trimethylsilanylmethyl-pent-4-enyl)-6-(3-trimethylsilanyl-prop-2-ynyl)-3,6-dihydro-2H-pyran 
• 911834-93-0 (Z)-(5S,6S)-5,6-Bis-(tert-butyl-dimethyl-silanyloxy)-octa-3,7-dien-1-ol 
• 911834-94-1 (Z)-(5S,6S)-5,6-Bis-(tert-butyl-dimethyl-silanyloxy)-octa-3,7-dienal 
• 873195-64-3 (E)-(5S,6S)-5,6-Bis-(tert-butyl-dimethyl-silanyloxy)-octa-2,7-dienal 
• 911834-82-7 tert-Butyl-[(Z)-4-((4S,5S)-2,2-dimethyl-5-vinyl-[1,3]dioxolan-4-yl)-but-3-enyloxy]-dimethyl-silane 
• 1058706-86-7 (S,S)-2,2-dimethyl-4-[(tert-butyldimethylsilyloxy)methyl]-5-vinyl-1,3-dioxolane 
• 911834-88-3 (E)-(1R,7S,11S,15S,17R)-7-((E)-(S)-3-Cyclohexyl-1-hydroxy-allyl)-11-methoxymethoxy-15-methyl-13-methylene-6,21-dioxa-bicyclo[15.3.1]henicosa-9,19-dien-3-yn-5-one 

Downstream Products

• 911834-91-8 (3Z,9E)-(1R,7S,11S,15S,17R)-7-((E)-(S)-3-Cyclohexyl-1-hydroxy-allyl)-11-hydroxy-15-methyl-13-methylene-6,21-dioxa-bicyclo[15.3.1]henicosa-3,9,19-trien-5-one 
• 911834-92-9 (Z)-(1R,3S,7S,8S,10S,12S,18R)-12-((E)-(S)-3-Cyclohexyl-1-hydroxy-allyl)-7-hydroxy-3-methyl-5-methylene-9,13,22-trioxa-tricyclo[16.3.1.0^8,10]docosa-15,19-dien-14-one 

Relevant academic research and scientific papers

Pharmacophore mapping in the laulimalide series: Total synthesis of a vinylogue for a late-stage metathesis diversification strategy

An efficient synthesis of the macrocyclic core of laulimalide with a pendant vinyl group at C20 is described, allowing for late-stage introduction of various side chains through a selective and efficient cross metathesis diversification step. Representati