91186-80-0Relevant academic research and scientific papers
Discovery of novel 5-oxa-2,6-diazaspiro[3.4]oct-6-ene derivatives as potent, selective, and orally available somatostatin receptor subtype 5 (SSTR5) antagonists for treatment of type 2 diabetes mellitus
Hirose, Hideki,Yamasaki, Takeshi,Ogino, Masaki,Mizojiri, Ryo,Tamura-Okano, Yumiko,Yashiro, Hiroaki,Muraki, Yo,Nakano, Yoshihide,Sugama, Jun,Hata, Akito,Iwasaki, Shinji,Watanabe, Masanori,Maekawa, Tsuyoshi,Kasai, Shizuo
, p. 4175 - 4193 (2017)
Somatostatin receptor subtype 5 (SSTR5) has emerged as a novel attractive drug target for type 2 diabetes mellitus. Starting from N-benzyl azetidine derivatives 1 and 2 as in-house hit compounds, we explored the introduction of a carboxyl group into the t
