Bioorganic and Medicinal Chemistry p. 4175 - 4193 (2017)
Update date:2022-08-15
Topics:
Hirose, Hideki
Yamasaki, Takeshi
Ogino, Masaki
Mizojiri, Ryo
Tamura-Okano, Yumiko
Yashiro, Hiroaki
Muraki, Yo
Nakano, Yoshihide
Sugama, Jun
Hata, Akito
Iwasaki, Shinji
Watanabe, Masanori
Maekawa, Tsuyoshi
Kasai, Shizuo
Somatostatin receptor subtype 5 (SSTR5) has emerged as a novel attractive drug target for type 2 diabetes mellitus. Starting from N-benzyl azetidine derivatives 1 and 2 as in-house hit compounds, we explored the introduction of a carboxyl group into the t
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