91189-27-4Relevant articles and documents
Quinolone Antibacterial Agents Substituted at the 7-Position with Spiroamines. Synthesis and Structure-Activity Relationships
Culbertson, Townley P.,Sanchez, Joseph P.,Gambino, Laura,Sesnie, Josephine A.
, p. 2270 - 2275 (2007/10/02)
A series of fluoroquinolone antibacterials having the 7-position (10-position of pyridobenzoxazines) substituted with 2,7-diazaspirononane (4b), 1,7-diazaspirononane (5a), or 2,8-diazaspiroundecane (6b) was prepared, and their biological activities were compared with piperazine and pyrrolidine substituted analogues.Most exhibited potent Gram-positive and Gram-negative activity, especially when side chain 4b was N-alkylated.
Antibacterial agents
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, (2008/06/13)
Novel naphthyridine-, quinoline- and benzoxazine-carboxylic acids as antibacterial agents are described as well as methods for their manufacture, formulation, and use in treating bacterial infections including the description of certain novel intermediates used in the manufacture of the antibacterial agents.
SYNTHESIS AND ABSOLUTE CONFIGURATION OF THREE ISOMERIC SPIRO-BIS(2-PYRROLIDINONES)
Kajtar, Marton,Hollosi, Miklos,Kinsky, Klaus,Majer, Zsuzsanna
, p. 936 - 949 (2007/10/02)
Syntheses are described for three isomeric spiro-bis-(2-pyrrolidinones): 2,7-diazaspirononane-3,8-dione (II), 2,7-diazaspirononane-1,8-dione (IV) and 1,7-diazaspirononane-2,8-dione (VI).All the syntheses were carried out starting from 3-carboxy-5-oxo-3-pyrrolidineacetic acid (VIII) of known configuration, allowing the assignation of absolute configuration to compounds II, IV and VI synthetized through stereochemically unequivocal reaction steps.