91193-02-1

Upstream product

• 4412-08-2 3-methyl-2-phenylbut-2-enoic acid 
• 114-70-5 sodium phenylacetate 
• 3127-67-1 2-phenyl-but-2-enoic acid 
• 103-82-2 phenylacetic acid 
• 6343-61-9 3-Hydroxy-3-methyl-2-phenylbutanoic acid 

Downstream Products

• 64859-24-1 N-Phenyl-3-methyl-2-phenyl-2-butenamid 
• 1072810-07-1 C₁₈H₁₉NO₂ 
• 1072810-06-0 C₁₂H₁₅NO₂ 

Relevant academic research and scientific papers

Electrochemical oxidative: Z -selective C(sp2)-H chlorination of acrylamides

An electrochemical method for the oxidative Z-selective C(sp2)-H chlorination of acrylamides has been developed. This catalyst and organic oxidant free method is applicable across various substituted tertiary acrylamides, and provides access to a broad range of synthetically useful Z-β-chloroacrylamides in good yields (22 examples, 73% average yield). The orthogonal derivatization of the products was demonstrated through chemoselective transformations and the electrochemical process was performed on gram scale in flow.

Stereospecific Electrophilic Fluorocyclization of α,β-Unsaturated Amides with Selectfluor

An efficient fluorocyclization of α,β-unsaturated amides through a formal halocyclization process is developed. The reaction proceeds under transition-metal-free conditions and leads to the formation of fluorinated oxazolidine-2,4-diones with excellent regio- and diastereoselectivity. The evaluation of the reaction mechanism based on preliminary experiments and density functional theory calculations suggests that a synergetic syn-oxo-fluorination occurs and is followed by an anti-oxo substitution reaction. The reaction opens a new window in the field of stereospecific fluorofunctionalization.

Synthesis of β-, γ-, and δ-lactams via Pd(II)-catalyzed C-H activation reactions

Pd(II)-catalyzed intramolecular amination of sp2 and sp3 C-H bonds are developed using a combination of CuCl2 and AgOAc as the oxidant. The reaction protocol tolerates the presence of a double bond in the substrates. This catalytic reaction provides practical access to a wide range of β-, γ-, and δ-lactams. Copyright