91228-44-3Relevant academic research and scientific papers
Genetically Encoded 2-Aryl-5-carboxytetrazoles for Site-Selective Protein Photo-Cross-Linking
Tian, Yulin,Jacinto, Marco Paolo,Zeng, Yu,Yu, Zhipeng,Qu, Jun,Liu, Wenshe R.,Lin, Qing
supporting information, p. 6078 - 6081 (2017/05/09)
The genetically encoded photo-cross-linkers promise to offer a temporally controlled tool to map transient and dynamic protein-protein interaction complexes in living cells. Here we report the synthesis of a panel of 2-aryl-5-carboxytetrazole-lysine analogs (ACTKs) and their site-specific incorporation into proteins via amber codon suppression in Escherichia coli and mammalian cells. Among five ACTKs investigated, N-methylpyrroletetrazole-lysine (mPyTK) was found to give robust and site-selective photo-cross-linking reactivity in E. coli when placed at an appropriate site at the protein interaction interface. A comparison study indicated that mPyTK exhibits higher photo-cross-linking efficiency than a diazirine-based photo-cross-linker, AbK, when placed at the same location of the interaction interface in vitro. When mPyTK was introduced into the adapter protein Grb2, it enabled the photocapture of EGFR in a stimulus-dependent manner. The design of mPyTK along with the identification of its cognate aminoacyl-tRNA synthetase makes it possible to map transient protein-protein interactions and their interfaces in living cells.
Pd(0)-Mediated 11C-Carbonylation of Aryl(mesityl)iodonium Salts as a Route to [11C]Arylcarboxylic Acids and Derivatives
Altomonte, Stefano,Telu, Sanjay,Lu, Shuiyu,Pike, Victor W.
, p. 11925 - 11932 (2017/11/24)
Pd(0)-mediated 11C-carbonylation of aryl(mesityl)iodonium salts followed by suitable quench provides a rapid room-temperature two-pot procedure for labeling arylcarboxylic acids and amide derivatives with the short-lived positron emitter carbon
Transition-Metal-Free N-Arylation of Pyrazoles with Diaryliodonium Salts
Gonda, Zsombor,Novák, Zoltán
supporting information, p. 16801 - 16806 (2015/11/16)
A new synthetic method was developed for the N-arylation of pyrazoles using diaryliodonium salts. The transformation does not require any transition-metal catalyst and provides the desired N-arylpyrazoles rapidly under mild reaction condition in the presence of aqueous ammonia solution as a mild base without the use of inert atmosphere. The chemoselectivity of unsymmetric diaryliodonium salts was also explored with large number of examples.
Fluoroalcohols: Versatile solvents in hypervalent iodine chemistry and syntheses of diaryliodonium(III) salts
Dohi, Toshifumi,Yamaoka, Nobutaka,Kita, Yasuyuki
experimental part, p. 5775 - 5785 (2010/09/14)
We first introduced 1,1,1,3,3,3-hexafluoroisopropanol (HFIP) and 2,2,2-trifluoroethanol (TFE) as unique solvents for reactions involving hypervalent iodine-mediated phenolic oxidations in the 1980s, in which the fluoroalcohols have been successfully utili
One-pot synthesis of diaryliodonium salts using toluenesulfonic acid: A fast entry to electron-rich diaryliodonium tosylates and triflates
Zhu, Mingzhao,Jalalian, Nazli,Olofsson, Berit
, p. 592 - 596 (2008/12/22)
A direct synthesis of symmetric and unsymmetric electron-rich diaryliodonium salts is described. The use of MCPBA and toluenesulfonic acid delivers diaryliodonium tosylates in high yields. An in situ anion exchange has also been developed, giving access to the corresponding triflate salts. Georg Thieme Verlag Stuttgart.
New synthesis of diaryliodonium sulfonates from arylboronic acids
Carroll, Michael A.,Pike, Victor W.,Widdowson, David A.
, p. 5393 - 5396 (2007/10/03)
Diaryliodonium salts, precursors to [18F]fluoroaromatics, have been prepared, in a regioselective manner, from readily available arylboronic acids eliminating the need for acid sensitive and toxic organotin intermediates. (C) 2000 Elsevier Science Ltd.
