912285-67-7Relevant academic research and scientific papers
A convenient synthesis of fluorine-containing dihydrobenzo[b][1,4]diazepinols and its application to a synthesis of novel N-sulfinylanilines
Ota, Norio,Tomoda, Takehisa,Terai, Naoya,Kamitori, Yasuhiro,Shibata, Dai,Medebielle, Maurice,Okada, Etsuji
experimental part, p. 1205 - 1217 (2009/06/28)
The reactions of 1,1,1,5,5,5-hexafluoro-3-(isobutoxymethylene)pentane-2,4-dione (1) with various benzene- 1,2-diamines gave 2,5-dihydro-3-trifluoroacetyl-2-trifluoromethyl-1H-benzo[b][1,4]diazepin es (5) in moderate to high yields under very mild conditions. Also, 2,5-dihydro-3-perhaloalkanoyl-2-perhaloalkyl-1H-benzo[b][1,4]diazepines (7) were synthesized successfully by quite similar manner. Reactions of thus obtained dihydrobenzo[b][1,4]diazepinols (5) with thionyl chloride gave unexpected novel fluorine-containing N-sulfinylanilines (9).
