39070-63-8

Basic information

• Product Name: (3,4-Diaminophenyl)phenylmethanone
• Synonyms: 3,4-Diaminodiphenylketone;LABOTEST-BB LT00159644;DIAMINOBENZOPHENONE-3,4;4-BENZOYL-1,2-PHENYLENEDIAMINE;3,4-DIAMINOBENZOPHENONE;(3,4-DIAMINOPHENYL)PHENYLMETHANONE;4-benzoyl-o-phenylenediamine;3,4-DIAMINOBENZOPHENONE 99%
• CAS NO: 39070-63-8
• Molecular Formula: C₁₃H₁₂N₂O
• Molecular Weight: 212.25
• EINECS: 254-273-8
• Product Categories: FINE Chemical & INTERMEDIATES;Aromatic Benzophenones & Derivatives (substituted)
• Mol File: 39070-63-8.mol
• Article Data: 8

Chemical Properties

• Melting Point: 115-117 °C(lit.)
• Boiling Point: 352.09°C (rough estimate)
• Flash Point: 220.3 °C
• Appearance: Yellow to ochre-yellow/Powder
• Density: 1.1128 (rough estimate)
• Vapor Pressure: 5.76E-08mmHg at 25°C
• Refractive Index: 1.6920 (estimate)
• Storage Temp.: Store below +30°C.
• Solubility: 0.4g/l
• PKA: 2.96±0.10(Predicted)
• Water Solubility: 410 mg/L (20 ºC)
• BRN: 2212487
• CAS DataBase Reference: (3,4-Diaminophenyl)phenylmethanone(CAS DataBase Reference)
• NIST Chemistry Reference: (3,4-Diaminophenyl)phenylmethanone(39070-63-8)
• EPA Substance Registry System: (3,4-Diaminophenyl)phenylmethanone(39070-63-8)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36-37/39
• WGK Germany: 3
• F: 9-23
• Hazardous Substances Data: 39070-63-8(Hazardous Substances Data)

Usage

Uses

3,4-Diaminobenzophenone is used in the synthesis of 2-Amino-5(6)-benzoylbenzimidazole (A593760), which is a minor urinary metabolite of Mebendazole (M200500) in man. Mebendazole impurity.

Purification Methods

Crystallise it from *C6H6/pet ether and sublime it in vacuo [Ayyanger et al. Org Prep Proced Int 23 627 1991].

InChI:InChI=1/C13H12N2O/c14-11-7-6-10(8-12(11)15)13(16)9-4-2-1-3-5-9/h1-8H,14-15H2

Synthetic route

2-nitro-4-benzoylaniline (31431-19-3) → 4-benzoylbenzene-1,2-diamine (39070-63-8)

Conditions	Yield
With pyrrolidine In 5,5-dimethyl-1,3-cyclohexadiene at 20 - 60℃; for 5h; Reagent/catalyst; Temperature;	98.9%
With sodium sulfide for 5h; Reduction; Heating;	90%
(i) Fe, aq. NH4Cl, (ii) aq. HCl; Multistep reaction;
With tin(ll) chloride In ethanol Heating;
With sulfur; sodium hydroxide In methanol at 78 - 80℃;

3,4-dinitrobenzophenone (33609-48-2) → 4-benzoylbenzene-1,2-diamine (39070-63-8)

Conditions	Yield
With hydrogen; nickel In tetrahydrofuran at 30 - 40℃;
With palladium 10% on activated carbon; hydrogen In methanol at 20℃; for 24h;

N-(4-benzoylphenyl)acetamide (4834-61-1) → 4-benzoylbenzene-1,2-diamine (39070-63-8)

Conditions	Yield
Multi-step reaction with 3 steps 1: 95 percent / fuming HNO3 2: aq. NaOH / methanol / Heating 3: 90 percent / aq. Na2S / 5 h / Heating View Scheme

4-acetamido-3-nitrobenzophenone (53502-23-1) → 4-benzoylbenzene-1,2-diamine (39070-63-8)

Conditions	Yield
Multi-step reaction with 2 steps 1: aq. NaOH / methanol / Heating 2: 90 percent / aq. Na2S / 5 h / Heating View Scheme

N-phenyl methyl carbamate (2603-10-3) + phloroglucinoldicarboxylic acid ester → 4-benzoylbenzene-1,2-diamine (39070-63-8)

Conditions	Yield
Multi-step reaction with 4 steps 1: 98 percent / AlCl3 / 1,2-dichloro-ethane / 5 h / 0 - 5 °C 2: 96 percent / fuming HNO3 / 0.75 h / 0 - 25 °C 3: 94 percent / aq. NaOH / methanol / 3 h / Heating 4: 90 percent / aq. Na2S / 5 h / Heating View Scheme

Methyl N-(4-benzoylphenyl)carbamate (134919-56-5) → 4-benzoylbenzene-1,2-diamine (39070-63-8)

Conditions	Yield
Multi-step reaction with 3 steps 1: 96 percent / fuming HNO3 / 0.75 h / 0 - 25 °C 2: 94 percent / aq. NaOH / methanol / 3 h / Heating 3: 90 percent / aq. Na2S / 5 h / Heating View Scheme

Methyl N-(4-benzoyl-2-nitrophenyl)carbamate (136023-33-1) → 4-benzoylbenzene-1,2-diamine (39070-63-8)

Conditions	Yield
Multi-step reaction with 2 steps 1: 94 percent / aq. NaOH / methanol / 3 h / Heating 2: 90 percent / aq. Na2S / 5 h / Heating View Scheme

Benzotrichlorid (98-07-7) → 4-benzoylbenzene-1,2-diamine (39070-63-8)

Conditions	Yield
Multi-step reaction with 4 steps 1: 98 percent / AlCl3 / 1,2-dichloro-ethane / 5 h / 0 - 5 °C 2: 96 percent / fuming HNO3 / 0.75 h / 0 - 25 °C 3: 94 percent / aq. NaOH / methanol / 3 h / Heating 4: 90 percent / aq. Na2S / 5 h / Heating View Scheme

3,4-dinitrobenzoic acid (528-45-0) → 4-benzoylbenzene-1,2-diamine (39070-63-8)

Conditions	Yield
Multi-step reaction with 2 steps 1: 1.) SOCl2, 2.) AlCl3 / 1.) reflux, 10 min, 2.) room temp., 24 h, then 40-50 deg C, 0.5 h 2: H2 / Raney nickel / tetrahydrofuran / 30 - 40 °C View Scheme
Multi-step reaction with 3 steps 1: thionyl chloride / N,N-dimethyl-formamide / 0 °C 2: aluminum (III) chloride / dichloromethane / 3 h / Reflux; Inert atmosphere 3: palladium 10% on activated carbon; hydrogen / methanol / 24 h / 20 °C View Scheme

3,4-Dinitrotoluene (610-39-9) → 4-benzoylbenzene-1,2-diamine (39070-63-8)

Conditions	Yield
Multi-step reaction with 3 steps 1: 75 percent / CrO3, aq. H2SO4 / 1.) 35 deg C, 0.5 h, 2.) 45-55 deg C, 4 h 2: 1.) SOCl2, 2.) AlCl3 / 1.) reflux, 10 min, 2.) room temp., 24 h, then 40-50 deg C, 0.5 h 3: H2 / Raney nickel / tetrahydrofuran / 30 - 40 °C View Scheme

4-methyl-2-nitro-1-nitrosobenzene (6971-33-1) → 4-benzoylbenzene-1,2-diamine (39070-63-8)

Conditions	Yield
Multi-step reaction with 4 steps 1: 8 g / aq. HNO3 / 0.08 h 2: 75 percent / CrO3, aq. H2SO4 / 1.) 35 deg C, 0.5 h, 2.) 45-55 deg C, 4 h 3: 1.) SOCl2, 2.) AlCl3 / 1.) reflux, 10 min, 2.) room temp., 24 h, then 40-50 deg C, 0.5 h 4: H2 / Raney nickel / tetrahydrofuran / 30 - 40 °C View Scheme

4-methyl-2-nitroaniline (89-62-3) → 4-benzoylbenzene-1,2-diamine (39070-63-8)

Conditions	Yield
Multi-step reaction with 5 steps 1: 89 percent / K2S2O8, H2SO4 / 24 h 2: 8 g / aq. HNO3 / 0.08 h 3: 75 percent / CrO3, aq. H2SO4 / 1.) 35 deg C, 0.5 h, 2.) 45-55 deg C, 4 h 4: 1.) SOCl2, 2.) AlCl3 / 1.) reflux, 10 min, 2.) room temp., 24 h, then 40-50 deg C, 0.5 h 5: H2 / Raney nickel / tetrahydrofuran / 30 - 40 °C View Scheme

4-chloro-3-nitrobenzophenone (56107-02-9) → 4-benzoylbenzene-1,2-diamine (39070-63-8)

Conditions	Yield
Multi-step reaction with 2 steps 1: NH3 2: (i) Fe, aq. NH4Cl, (ii) aq. HCl View Scheme
Multi-step reaction with 2 steps 1: ammonia / 130 - 135 °C / 4500.45 - 5250.53 Torr 2: sulfur; sodium hydroxide / methanol / 78 - 80 °C View Scheme

3,4-dinitrobenzoyl chloride (24376-18-9) → 4-benzoylbenzene-1,2-diamine (39070-63-8)

Conditions	Yield
Multi-step reaction with 2 steps 1: aluminum (III) chloride / dichloromethane / 3 h / Reflux; Inert atmosphere 2: palladium 10% on activated carbon; hydrogen / methanol / 24 h / 20 °C View Scheme

para-chlorotoluene (106-43-4) → 4-benzoylbenzene-1,2-diamine (39070-63-8)

Conditions	Yield
Multi-step reaction with 5 steps 1: nitric acid / 70 °C 2: nitric acid / 50 °C 3: thionyl chloride / N,N-dimethyl-formamide / 75 - 80 °C 4: ammonia / 130 - 135 °C / 4500.45 - 5250.53 Torr 5: sulfur; sodium hydroxide / methanol / 78 - 80 °C View Scheme

para-chlorobenzoic acid (74-11-3) → 4-benzoylbenzene-1,2-diamine (39070-63-8)

Conditions	Yield
Multi-step reaction with 4 steps 1: nitric acid / 50 °C 2: thionyl chloride / N,N-dimethyl-formamide / 75 - 80 °C 3: ammonia / 130 - 135 °C / 4500.45 - 5250.53 Torr 4: sulfur; sodium hydroxide / methanol / 78 - 80 °C View Scheme

4-chloro-3-nitrobenzoate (96-99-1) → 4-benzoylbenzene-1,2-diamine (39070-63-8)

Conditions	Yield
Multi-step reaction with 3 steps 1: thionyl chloride / N,N-dimethyl-formamide / 75 - 80 °C 2: ammonia / 130 - 135 °C / 4500.45 - 5250.53 Torr 3: sulfur; sodium hydroxide / methanol / 78 - 80 °C View Scheme

4-benzoylbenzene-1,2-diamine (39070-63-8) + 4,4'-dibromobenzil (35578-47-3) → (2,3-bis(4-bromophenyl)quinoxalin-6-yl)(phenyl)methanone (1352635-46-1)

Conditions	Yield
With titanium(IV) oxide In 1,2-dichloro-ethane at 25℃; for 0.5h;	99%
With niobium pentachloride In ethanol at 20℃; for 0.0833333h;	94%
With acetic acid Reflux;	90%
With acetic acid for 8h; Reflux;	80%

4-benzoylbenzene-1,2-diamine (39070-63-8) + dimethylglyoxal (431-03-8) → (2,3-dimethylquinoxalin-6-yl)(phenyl)methanone (119426-73-2)

Conditions	Yield
In neat (no solvent) at 24.84℃;	98%
With 1-methyl-3-(3-trimethoxysilylpropyl)imidazolium hydrogen sulfate immobilized on cellulose In water at 20℃; for 0.0833333h; Green chemistry;	97%
With PEG-400 at 110℃; for 0.416667h; Neat (no solvent);	92%

4-benzoylbenzene-1,2-diamine (39070-63-8) + furil (492-94-4) → (2,3-di(furan-2-yl)quinoxalyn-6-yl)(phenyl)methanone

Conditions	Yield
With gallium(III) triflate In ethanol at 20℃; for 0.166667h;	98%
With H3PMo12O40 nanoparticles immobilized on imidazole functionalized core-shell Fe3O4(at)SiO2 nanoparticle In ethanol at 20℃; for 0.333333h; Green chemistry;	95%
With titanium(IV) oxide In 1,2-dichloro-ethane at 25℃; for 1.25h;	91%

glycolic Acid (79-14-1) + 4-benzoylbenzene-1,2-diamine (39070-63-8) → (2-hydroxymethyl-1(3)H-benzoimidazol-5-yl)-phenyl-methanone (66353-67-1)

Conditions	Yield
With hydrogenchloride In water at 100℃; for 2h;	98%

4-benzoylbenzene-1,2-diamine (39070-63-8) + 9,10-phenanthrenequinone (84-11-7) → 11-benzoyldibenzophenazine

Conditions	Yield
With tungstate sulfuric acid at 20℃; for 0.333333h; Neat (no solvent);	98%
With lithium chloride In ethanol at 20℃; for 0.666667h;	97%
With lead(II) chloride In ethanol at 20℃; for 0.25h;	97%

4-benzoylbenzene-1,2-diamine (39070-63-8) + acenaphthene quinone (82-86-0) → 11-benzoyldibenzophenazine

Conditions	Yield
With magnesium sulfate heptahydrate In ethanol at 20℃; for 0.166667h;	98%

4-benzoylbenzene-1,2-diamine (39070-63-8) + 4-dimethylamino-benzaldehyde (100-10-7) → [2-(4-dimethylamino-phenyl)-1H-benzoimidazol-5-yl](phenyl)methanone

Conditions	Yield
With sodium metabisulfite In ethanol; water at 20℃; for 2h;	98%

5-iodovaniline (5438-36-8) + 4-benzoylbenzene-1,2-diamine (39070-63-8) → (2-(4-hydroxy-3-iodo-5-methoxyphenyl)-1H-benzoimidazol-5-yl)(phenyl)methanone

Conditions	Yield
With sodium metabisulfite In ethanol; water at 20℃; for 2h;	98%

4-benzoylbenzene-1,2-diamine (39070-63-8) + benzil (134-81-6) → 6-benzoyl-2,3-diphenylquinoxaline (150252-47-4)

Conditions	Yield
With silica gel at 20 - 100℃; for 2h; Neat (no solvent);	97%
With 1-methyl-3-(3-trimethoxysilylpropyl)imidazolium hydrogen sulfate immobilized on cellulose In water at 20℃; for 0.166667h; Green chemistry;	97%
With gallium(III) triflate In ethanol at 20℃; for 0.333333h;	95%

4-benzoylbenzene-1,2-diamine (39070-63-8) + 4-Nitrophenyl isocyanate (100-28-7) → C20H16N4O4 (1315320-49-0)

Conditions	Yield
In dichloromethane at 20℃; for 24h;	97%

4-benzoylbenzene-1,2-diamine (39070-63-8) + furoin (552-86-3) → (2,3-di(furan-2-yl)quinoxalyn-6-yl)(phenyl)methanone

Conditions	Yield
With [P4-VP]-PdNPs In N,N-dimethyl-formamide at 120℃; for 0.0833333h; Reflux;	97%
With silica sulfuric acid; PEG-400 at 120℃; for 6h;	52%

carbon disulfide (75-15-0) + 4-benzoylbenzene-1,2-diamine (39070-63-8) → (2-mercapto-1H-benzo[d]imidazol-6-yl)(phenyl)methanone (92685-57-9)

Conditions	Yield
With sodium hydroxide In ethanol; water for 3h; Reflux;	96.8%
With sodium hydroxide In ethanol Reflux;	96.8%
Stage #1: carbon disulfide With potassium hydroxide In methanol Reflux; Stage #2: 4-benzoylbenzene-1,2-diamine In methanol for 10h; Reflux;	69%

4-benzoylbenzene-1,2-diamine (39070-63-8) + 3,3,6,6-tetrachloro-1,2-cyclohexanedione (96147-14-7) → 7-benzoyl-1,1,4,4-tetrachloro-1,2,3,4-tetrahydrophenazine

Conditions	Yield
In chloroform for 1h; Ambient temperature;	96%

4-benzoylbenzene-1,2-diamine (39070-63-8) + 4-isothiocyanato-4-methylpentan-2-one (27248-25-5) → [4-amino-3-(4,4,6-trimethyl-2-thioxo-3,4-dihydro-2H-pyrimidin-1-yl)-phenyl]-phenyl-methanone

Conditions	Yield
In tetrahydrofuran for 48h; Ambient temperature;	96%

dimethyl N-benzoyldithiocarbonimidate (24786-18-3) + 4-benzoylbenzene-1,2-diamine (39070-63-8) → N-(5-benzoyl-1H-benzimidazol-2-yl)benzamide

Conditions	Yield
In N,N-dimethyl-formamide at 150℃; for 9h;	96%

di-tert-butyl dicarbonate (24424-99-5) + 4-benzoylbenzene-1,2-diamine (39070-63-8) → N, N'-di-(tert-butoxycarbonyl)-3,4-diaminobenzophenone (1282523-82-3)

Conditions	Yield
With guanidine hydrochloride In ethanol at 35 - 40℃; for 3.5h;	96%

4-benzoylbenzene-1,2-diamine (39070-63-8) + 1,3-Dichloroacetone (534-07-6) → 2,2-bis(chloromethyl)-5-benzoyl-2,3-dihydro-1H-benzo[d]imidazole (1093377-34-4)

Conditions	Yield
at 60℃; for 0.25h; Neat (no solvent); grinding;	96%

4-benzoylbenzene-1,2-diamine (39070-63-8) + benzaldehyde (100-52-7) → phenyl (2-phenyl-1H-benzo[d]imidazol-5-yl)methanone (129545-20-6)

Conditions	Yield
With vanadium(IV)-salen complex nanoparticles immobilized onto silica In ethanol at 20℃; for 6h;	95%
With ammonium acetate In ethanol at 75℃; for 7.5h;	92%
With air In ethanol at 20℃; for 5.5h;	90%

4-benzoylbenzene-1,2-diamine (39070-63-8) → 5-Benzoylbenzotriazole (107508-46-3)

Conditions	Yield
With acetic acid; sodium nitrite In water at 20℃; for 12h;	95%
With acetic acid In water at 70 - 80℃; for 0.466667h;	87%

4-benzoylbenzene-1,2-diamine (39070-63-8) + acenaphthene quinone (82-86-0) → 9-benzoylacenaphtho<1,2-b>quinoxaline

Conditions	Yield
With niobium pentachloride In ethanol at 20℃; for 0.0666667h;	95%
With lithium chloride In ethanol at 20℃; for 0.75h;	95%
With lead(II) chloride In ethanol at 20℃; for 0.333333h;	95%

4-benzoylbenzene-1,2-diamine (39070-63-8) + 2-hydroxy-2-phenylacetophenone (119-53-9) → 6-benzoyl-2,3-diphenylquinoxaline (150252-47-4)

Conditions	Yield
With [P4-VP]-PdNPs In N,N-dimethyl-formamide at 120℃; for 0.116667h; Reflux;	95%
With potassium permanganate; copper(II) sulfate In ethanol for 2.5h; Reflux;	87%
With potassium fluoride on basic alumina at 80℃; for 7h;	79%
With silica sulfuric acid; PEG-400 at 120℃; for 6h;	51%
With oxygen In ethanol at 70℃; for 6h; Schlenk technique; Sealed tube; Green chemistry;

4-benzoylbenzene-1,2-diamine (39070-63-8) + 2,2-dihydroxy-1-phenyl-ethanone (1075-06-5) → [2-(4-phenyl)quinoxalin-6-yl](phenyl)methanone (1338368-84-5)

Conditions	Yield
With lithium chloride In ethanol at 20℃; for 0.666667h;	95%
With lead(II) chloride In ethanol at 20℃; for 0.333333h; Reagent/catalyst;	95%
With titanium(IV) oxide In 1,2-dichloro-ethane at 25℃; for 1.16667h;	90%

Trimethyl orthoacetate (1445-45-0) + 4-benzoylbenzene-1,2-diamine (39070-63-8) → 5-benzoyl-2-methyl benzimidazole (97375-60-5)

Conditions	Yield
With silica choride at 80℃; for 0.3h;	95%
With iron(II,III) oxide at 80℃; for 0.166667h;	88%
With tungstate sulfuric acid In neat (no solvent) at 80℃; for 0.583333h; Green chemistry;	85%

2,2-dihydroxy-1-(3-methoxyphenyl)ethanone (1201806-19-0) + 4-benzoylbenzene-1,2-diamine (39070-63-8) → 3-(3-methoxyphenyl)-7-benzoylquinoxaline

Conditions	Yield
With lead(II) chloride In ethanol at 20℃; for 0.333333h; Reagent/catalyst;	95%

4-benzoylbenzene-1,2-diamine (39070-63-8) + O-methyl-N-(methoxycarbonyl)-isourea (40943-37-1) → mebendazole (31431-39-7)

Conditions	Yield
With acetic acid In toluene	95%
With hydrogenchloride In chloroform Cooling with ice; Reflux;

Cyclohexyl isocyanide (931-53-3) + trimethylsilylazide (4648-54-8) + 4-benzoylbenzene-1,2-diamine (39070-63-8) + cyclohexanone (108-94-1) → {4a'-(1-cyclohexyl-1H-tetrazol-5-yl)-1',2',3',4',4a',5',10',11a'-octahydrospiro[cyclohexane-1,11'-dibenzo[b,e][1,4]diazepine]-7'-yl}(phenyl)methanone (1374754-04-7)

Conditions	Yield
With NiO39PW11(5-)*5C8H15N2(1+)*3H2O In methanol at 20℃; for 4h;	95%

m-bromobenzoic aldehyde (3132-99-8) + 4-benzoylbenzene-1,2-diamine (39070-63-8) → (2-(3-bromophenyl)-1H-benzo[d]imidazol-6-yl)(phenyl)methanone

Conditions	Yield
With nickel diacetate In chloroform at 60℃; Microwave irradiation; Green chemistry;	95%

4-benzoylbenzene-1,2-diamine (39070-63-8) + 1,2-bis(4-methoxyphenyl)-1,2-ethanedione (1226-42-2) → (2,3-bis(4-methoxyphenyl)quinoxalin-6-yl)(phenyl)methanone

Conditions	Yield
With titanium(IV) oxide In 1,2-dichloro-ethane at 25℃; for 1.5h;	94%
With zirconium triflate In ethanol; water at 20℃; for 0.333333h; Green chemistry;	94%
With H3PMo12O40 nanoparticles immobilized on imidazole functionalized core-shell Fe3O4(at)SiO2 nanoparticle In ethanol at 20℃; for 0.333333h; Green chemistry;	93%

2,2'-Pyridil (492-73-9) + 4-benzoylbenzene-1,2-diamine (39070-63-8) → phenyl(2,3-di(pyridin-2-yl)quinoxalin-6-yl)methanone (246518-07-0)

Conditions	Yield
With PEG-400 at 110℃; for 1h; Neat (no solvent);	94%
With polyethylene glycol-400 at 120℃; for 0.0833333h; Microwave irradiation;	91%
In glycerol at 90℃; for 0.133333h; Microwave irradiation; Green chemistry;	86%

Upstream product

• 33609-48-2 3,4-dinitrobenzophenone 
• 106-43-4 para-chlorotoluene 
• 74-11-3 para-chlorobenzoic acid 
• 96-99-1 4-chloro-3-nitrobenzoate 
• 24376-18-9 3,4-dinitrobenzoyl chloride 
• 56107-02-9 4-chloro-3-nitrobenzophenone 
• 610-39-9 3,4-Dinitrotoluene 
• 528-45-0 3,4-dinitrobenzoic acid 
• 98-07-7 Benzotrichlorid 
• 136023-33-1 Methyl N-(4-benzoyl-2-nitrophenyl)carbamate 
• 2603-10-3 N-phenyl methyl carbamate 
• 53502-23-1 4-acetamido-3-nitrobenzophenone 
• 4834-61-1 N-(4-benzoylphenyl)acetamide 
• 31431-19-3 2-nitro-4-benzoylaniline 

Downstream Products

• 70122-22-4 3-(p-Chlorphenylmethylenimino)-4-aminobenzophenon 
• 129545-20-6 phenyl (2-phenyl-1H-benzo[d]imidazol-5-yl)methanone 
• 302941-71-5 8-benzoyl-1,1,4-trichloro-1,2,3,4-tetrahydrophenazine 
• 364043-43-6 2-(5-benzoyl-1,3-dihydro-benzoimidazol-2-ylidene)-malononitrile 
• 216387-91-6 phenyl(2,3-diphenyl-6-quinoxalinyl)carbinol 

Relevant articles and documents

A preparing method of a mebendazole intermediate (3,4-diaminophenyl)phenyl methanone

A preparing method of a mebendazole intermediate (3,4-diaminophenyl)phenyl methanone is disclosed. The method includes adding 4-amino-3-nitro diphenylmethanone and a catalyst into an organic solvent, adding a hydrogen donor, and performing transfer hydrogenation reduction to obtain the (3,4-diaminophenyl)phenyl methanone, wherein the catalyst is a Pd-X/C catalyst, and the X is one of Ni, Ru, La, Ce, Co, Li, K, Mg, Ti, Cu or Mo. The method has advantages of mild conditions, simple operation, a high reduction rate, a low cost, high environment protection performance, easy industrial production, and the like.

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