912359-80-9

Basic information

• Product Name: Deacetyl (R)-Linezolid
• Synonyms: Deacetyl (R)-Linezolid
• CAS NO: 912359-80-9
• Molecular Formula: C₁₄H₁₈FN₃O₃
• Molecular Weight: 295.3094232
• Product Categories: Aromatics, Chiral Reagents, Heterocycles, Impurities, Pharmaceuticals, Intermediates & Fine Chemicals
• Mol File: 912359-80-9.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 480.0±45.0 °C(Predicted)
• Appearance: /
• Density: 1.319±0.06 g/cm3(Predicted)
• Storage Temp.: Refrigerator
• Solubility: Chloroform (Slightly), Methanol (Slightly)
• PKA: 8.96±0.29(Predicted)
• CAS DataBase Reference: Deacetyl (R)-Linezolid(CAS DataBase Reference)
• NIST Chemistry Reference: Deacetyl (R)-Linezolid(912359-80-9)
• EPA Substance Registry System: Deacetyl (R)-Linezolid(912359-80-9)

Safety Data

• Hazardous Substances Data: 912359-80-9(Hazardous Substances Data)

Usage

Uses

Deacetyl (R)-Linezolid is an impurity of (R)-Linezolid (L466505).

Upstream product

• 168828-84-0 (R)-5-azidomethyl-3-(3-fluoro-4-(morpholin-4-yl)phenyl)oxazolidin-2-one 
• 168828-82-8 (R)-3-(3-fluoro-4-morpholinophenyl)-2-oxo-5-oxazolidinyl methanol 
• 565176-83-2 N-ethoxycarbonyl-3-fluoro-4-morpholinyl aniline 
• 2689-39-6 3-fluoro-4-(4-morpholinyl)nitrobenzene 
• 369-34-6 3,4-difluoronitrobenzene 
• 858344-36-2 methanesulfonic acid 3-(3-fluoro-4-morpholin-4-ylphenyl)-2-oxo-oxazolidin-5-ylmethyl ester 
• 513068-96-7 3-(3-fluoro-4-morpholin-4-yl-phenyl)-5-hydroxymethyl-oxazolidin-2-one 
• 93246-53-8 3-fluoro-4-(morpholinyl)aniline 
• 1385053-40-6 C₁₈H₂₅FN₂O₄ 
• 952680-48-7 (3-fluoro-4-morpholin-4-yl-phenyl)carbamic acid tert-butyl ester 
• 1352030-06-8 N-[[3-[3-fluoro-4-(4-morpholinyl)phenyl]-2-oxo-5-oxazolidinyl]methyl]amine 

Downstream Products

• 165800-03-3 linezolid 

Relevant articles and documents

Synthesis of covalent bonding MWCNT-oligoethylene linezolid conjugates and their antibacterial activity against bacterial strains

Nowadays, infectious diseases caused by drug-resistant bacteria have become especially important. Linezolid is an antibacterial drug active against clinically important Gram positive strains; however, resistance showed by these bacteria has been reported. Nanotechnology has improved a broad area of science, such as medicine, developing new drug delivery and transport systems. In this work, several covalently bounded conjugated nanomaterials were synthesized from multiwalled carbon nanotubes (MWCNTs), a different length oligoethylene chain (Sn), and two linezolid precursors (4and7), and they were evaluated in antibacterial assays. Interestingly, due to the intrinsic antibacterial activity of the amino-oligoethylene linezolid analogues, these conjugated nanomaterials showed significant antibacterial activity against various tested bacterial strains in a radial diffusion assay and microdilution method, including Gram negative strains asEscherichia coli(11 mm, 6.25 μg mL?1) andSalmonella typhi(14 mm, ≤0.78 μg mL?1), which are not inhibited by linezolid. The results show a significant effect of the oligoethylene chain length over the antibacterial activity. Molecular docking of amino-oligoethylene linezolid analogs shows a more favorable interaction of theS2-7analog in the PTC ofE. coli.

A new method for the oxazolidinone key intermediate of linezolid and its formal synthesis

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