858344-36-2

Usage

Uses

Used in Pharmaceutical Industry:
3-[3-Fluoro-4-(4-morpholinyl)phenyl]-5-[[(methylsulfonyl)oxy]methyl]-2-oxazolidinone is used as a potential pharmaceutical agent for its possible antibiotic or antimicrobial properties due to the presence of the oxazolidinone ring. Its complex structure, including the sulfonyl group, also suggests potential applications in the development of new medications.
Used in Drug Discovery and Development:
3-[3-Fluoro-4-(4-morpholinyl)phenyl]-5-[[(methylsulfonyl)oxy]methyl]-2-oxazolidinone serves as a promising candidate for drug discovery and development. Its unique chemical composition and potential medicinal properties make it an interesting subject for further research and exploration in the field of pharmaceuticals.

Upstream product

• 1385053-40-6 C₁₈H₂₅FN₂O₄ 
• 952680-48-7 (3-fluoro-4-morpholin-4-yl-phenyl)carbamic acid tert-butyl ester 
• 513068-92-3 3-{3-fluoro-4-morpholinophenyl}-5-(tetrahydro-2H-2-pyranyloxy-methyl)-2-oxazolidinone 
• 513068-89-8 4-(4-bromo-2-fluorophenyl)morpholine 
• 93246-53-8 3-fluoro-4-(morpholinyl)aniline 
• 124-63-0 methanesulfonyl chloride 
• 513068-96-7 3-(3-fluoro-4-morpholin-4-yl-phenyl)-5-hydroxymethyl-oxazolidin-2-one 

Downstream Products

• 1213258-42-4 3-(3-fluoro-4-morpholinophenyl)-5-((3-oxoisothiazol-2(3H)-yl)methyl)oxazolidin-2-one 
• 912359-80-9 (S)-[3-[3-fluoro-4-(4-morpholinyl)phenyl]-2-oxo-5-oxazolidinyl]aminomethane 
• 168828-90-8 (S)-N-[[3-[3-fluoro-4-[4-morpholinyl]phenyl]-2-oxo-5-oxazolidinyl]methyl]amine 
• 224323-50-6 linezolid 
• 165800-03-3 linezolid 
• 224323-50-6 linezolid 

Relevant academic research and scientific papers

Synthesis and antibacterial activity of isothiazolyl oxazolidinones and analogous 3(2H)-isothiazolones

The synthesis and antibacterial activity of several new 5-((3-oxoisothiazol-2(3H)-yl)methyl)-3-phenyloxazolidin-2-ones 8 and analogous 2-(4-substituted phenyl)-3(2H)-isothiazolones 3 and 4 substituted at 4 and/or 3-positions of the phenyl moiety with different groups of which some have shown to increase the antibacterial activity of both 3-aryl-2-oxazolidinones and 3(2H)-isothiazolones is described. The most active compounds were isothiazolyl oxazolidinones 8a,j with unsubstituted and 8b with 4-F substituted phenyl rings which showed activities higher than analogous 3(2H)-isothiazolones and comparable or superior to linezolid, vancomycin, and ciprofloxacin against some tested microorganisms. The change in position of F and/or the use of larger substituents gave compounds with reduced or no activity. Evaluation of cytotoxicity to mouse fibroblast (NIH/3T3) cells indicated that these compounds exhibit antibacterial activity at non-cytotoxic concentrations.

Highly efficient CuI-catalyzed coupling of aryl bromides with oxazolidinones using Buchwald's protocol: a short route to linezolid and toloxatone.

[reaction: see text] Coupling of a variety of substituted aryl bromides with oxazolidinones has been achieved using the Buchwald protocol for the amidation of aryl halides. This procedure is exemplified by the synthesis of two medicinally important molecules, linezolid and toloxatone.