912365-40-3Relevant academic research and scientific papers
Synthesis of camphorsulfonamide-based quinoline ligands and their N-oxides: first use in the enantioselective addition of organozinc reagents to aldehydes
Martinez, Ricardo,Zoli, Luca,Cozzi, Pier Giorgio,Ramon, Diego J.,Yus, Miguel
, p. 2600 - 2607 (2008)
The preparation of several camphorsulfonamide-based quinoline derivatives and their N-oxides was accomplished via an indirect Friedlaender synthesis using aminobenzylic alcohols and RuCl2(DMSO)4 as a catalyst. These ligands were tested in the enantioselective addition of dialkylzinc reagents to aldehydes, with enantiomeric excesses up to 96%. A similar protocol using triphenylborane and diethylzinc gave the corresponding phenylation process.
