912368-67-3 Usage
Description
3-cyano-3-(2-thienyl)acrylic acid potassium salt is a chemical compound with the molecular formula C7H5NO2S. It is a potassium salt of the acrylic acid derivative, known for its versatile chemical properties and strong nucleophilic and electrophilic characteristics in chemical reactions. 3-cyano-3-(2-thienyl)acrylic acid potassium salt plays a significant role in the field of organic chemistry, particularly in organic synthesis and pharmaceutical research.
Uses
Used in Pharmaceutical Research:
3-cyano-3-(2-thienyl)acrylic acid potassium salt is used as a reagent in pharmaceutical research for the development of various pharmaceuticals. Its unique chemical properties make it a valuable component in the synthesis of new drug molecules.
Used in Agrochemical Production:
In the agrochemical industry, 3-cyano-3-(2-thienyl)acrylic acid potassium salt is utilized as a reagent in the production of various agrochemicals. Its ability to participate in chemical reactions as both a nucleophile and electrophile contributes to the creation of effective agrochemical products.
Used in Organic Synthesis:
3-cyano-3-(2-thienyl)acrylic acid potassium salt is employed as a key component in organic synthesis, where it aids in the formation of complex organic molecules. Its versatility in chemical reactions allows for the synthesis of a wide range of organic compounds for various applications.
Check Digit Verification of cas no
The CAS Registry Mumber 912368-67-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 9,1,2,3,6 and 8 respectively; the second part has 2 digits, 6 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 912368-67:
(8*9)+(7*1)+(6*2)+(5*3)+(4*6)+(3*8)+(2*6)+(1*7)=173
173 % 10 = 3
So 912368-67-3 is a valid CAS Registry Number.
912368-67-3Relevant articles and documents
Adventures in Scaffold Morphing: Discovery of Fused Ring Heterocyclic Checkpoint Kinase 1 (CHK1) Inhibitors
Yang, Bin,Vasbinder, Melissa M.,Hird, Alexander W.,Su, Qibin,Wang, Haixia,Yu, Yan,Toader, Dorin,Lyne, Paul D.,Read, Jon A.,Breed, Jason,Ioannidis, Stephanos,Deng, Chun,Grondine, Michael,Degrace, Nancy,Whitston, David,Brassil, Patrick,Janetka, James W.
supporting information, p. 1061 - 1073 (2018/02/17)
Checkpoint kinase 1 (CHK1) inhibitors are potential cancer therapeutics that can be utilized for enhancing the efficacy of DNA damaging agents. Multiple small molecule CHK1 inhibitors from different chemical scaffolds have been developed and evaluated in clinical trials in combination with chemotherapeutics and radiation treatment. Scaffold morphing of thiophene carboxamide ureas (TCUs), such as AZD7762 (1) and a related series of triazoloquinolines (TZQs), led to the identification of fused-ring bicyclic CHK1 inhibitors, 7-carboxamide thienopyridines (7-CTPs), and 7-carboxamide indoles. X-ray crystal structures reveal a key intramolecular noncovalent sulfur-oxygen interaction in aligning the hinge-binding carboxamide group to the thienopyridine core in a coplanar fashion. An intramolecular hydrogen bond to an indole NH was also effective in locking the carboxamide in the preferred bound conformation to CHK1. Optimization on the 7-CTP series resulted in the identification of lead compound 44, which displayed respectable drug-like properties and good in vitro and in vivo potency.
