91240-91-4Relevant articles and documents
New 8-hydroxyquinoline derivatives highlight the potential of this class for treatment of fungal infections
Joaquim, Angélica Rocha,Reginatto, Paula,Lopes, Marcela Silva,Bazana, Luana Candice Genz,Gionbelli, Mariana Pies,de Cesare, Maycon Antonio,Kaminski, Taís Fernanda Andrzejewski,Teixeira, Mário Lettieri,Abegg, Maxwel Adriano,Fuentefria, Alexandre Meneghello,de Andrade, Saulo Fernandes
, p. 18158 - 18170 (2021/10/12)
The oral administration of clioquinol - a potent 8-hydroxyquinoline antimicrobial drug - was forbidden due to suspicion of it being the cause of SMON (subacute myelo-optic-neuropathy) in Japan. However, this adverse effect was only observed in Japan, desp
Synthesis of ortho-alkoxy-aryl carboxamides via alladium-catalyzed aminocarbonylation
Takacs, Attila,Abreu, Artur R.,Peixoto, Andreia F.,Pereira, Mariette,Kollar, Laszlo
body text, p. 1534 - 1548 (2009/10/17)
Various aryl carboxamides with alkoxy substituents at the ortho-position, applicable as direct intermediates toward novel ligands, were synthesised via aminocarbonylation of aryl-iodides (2-iodoanisole, 5-chloro-7-iodo-8-methoxy- quinoline, and 5-chloro-7-iodo-8-benzyloxy-quinoline) in the presence of in situ generated palladium(0) catalysts. Simple primary and secondary amines as well as aminoacid esters were used as N-nucleophiles. The optimization of the reaction conditions allowed the preferential formation of carboxamides or ketocarboxamides by simple or double carbon monoxide insertion, respectively. A strong dependence of the chemoselectivity on carbon monoxide pressure was observed. Copyright Taylor & Francis Group, LLC.
MASS SPECTROMETRY OF 8-HYDROXYQUINOLINE DERIVATIVES
Ermakov, A. I.,Voronin, V. G.,Sorokin, A. A.,Epshtein, N. I.,Muravskaya, I. D.,et al.
, p. 637 - 642 (2007/10/02)
In contrast to the fragmentation of the corresponding alkyl aryl ethers, characteristic + and + fragments were observed in the fragmentation of 5-nitro(halo)-substituted 8-alkoxyquinolines.It was found by means of deuterium labeling that a hydrogen atom is split out primarily from the alkoxy group.It was demonstrated that an + fragment was from the + ion, which has a three-ring structure and quaternary nitrogen atom.The formation of an + fragment is characteristic for the fragmentation of 5(7)-nitro(halo)-substituted 8-hydroxyquinolines.The interrelationship between the intensities of the +, +, and + ion peaks and the protonation constants (pKa) of the investigated compounds is discussed.
