Cliogoinol methyl derivative

Base Information

• Chemical Name: Cliogoinol methyl derivative
• CAS No.: 91240-91-4
• Molecular Formula: C10H7 Cl I N O
• Molecular Weight: 319.52615
• Mol file: 91240-91-4.mol

Synonyms:5-Chloro-7-iodo-8-methoxyquinoline

Chemical Property of Cliogoinol methyl derivative

Chemical Property:

• PSA: 22.12000
• LogP: 3.50140

Purity/Quality:

98.5% ^*data from raw suppliers

5-CHLORO-7-IODO-8-METHOXYQUINOLINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Cliogoinol methyl derivative

There total 2 articles about Cliogoinol methyl derivative which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

5-chloro-7-iodoquinolin-8-ol (130-26-7,22112-03-4) + methyl iodide (74-88-4) → chloro-5 iodo-7 methoxy-8 quinoline (91240-91-4)

Guidance literature:

5-chloro-7-iodoquinolin-8-ol; With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 0.5h;

methyl iodide; In N,N-dimethyl-formamide; at 20 ℃; for 16h;

DOI:10.1039/d0nj06188c

Reference yield:

5-chloro-7-iodoquinolin-8-ol (130-26-7,22112-03-4) + Methyl benzenesulfonate (80-18-2) → chloro-5 iodo-7 methoxy-8 quinoline (91240-91-4)

Guidance literature:

With sodium hydroxide;

DOI:10.1007/BF00508673

Reference yield: 81.0%

chloro-5 iodo-7 methoxy-8 quinoline (91240-91-4) + 4-fluoroaniline (371-40-4) → 5-chloro-7-(4-fluorophenylamino)-8-methoxyquinoline

Guidance literature:

With palladium diacetate; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; at 100 ℃; for 16h; Inert atmosphere; Sealed tube;

DOI:10.1039/d0nj06188c

upstream raw materials:

5-chloro-7-iodoquinolin-8-ol

Methyl benzenesulfonate

methyl iodide

Downstream raw materials:

chloro-5 methoxy-8 quinoleine

chloro-5 methoxy-8 thiomethyl-7 quinoleine

chloro-5 methoxy-8 thio(propionate d'ethyle-3)-7 quinoleine

Refernces

• 1、 Zhai, Shumei,Yang, Lei,Cui, Qiuzhi Cindy,Sun, Ying,Dou, Q. Ping,Yan, Bing. "Tumor cellular proteasome inhibition and growth suppression by 8-hydroxyquinoline and clioquinol requires their capabilities to bind copper and transport copper into cells". experimental part. p. 259 - 269. Retrieved 2011/12/16.
• 2、 Beugelmans,Bois-Choussy. "S(RN)1 reactions. XV. Action of sulfanions on clioquinol". . p. 1381 - 1388. Retrieved 2007/10/02.