912445-03-5

Basic information

• Product Name: (R)-2-benzyl 1-tert-butyl 2-methylpyrrolidine-1,2-dicarboxylate
• Synonyms: (R)-2-benzyl 1-tert-butyl 2-methylpyrrolidine-1,2-dicarboxylate
• CAS NO: 912445-03-5
• Molecular Weight: 319.401
• Mol File: 912445-03-5.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (R)-2-benzyl 1-tert-butyl 2-methylpyrrolidine-1,2-dicarboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-2-benzyl 1-tert-butyl 2-methylpyrrolidine-1,2-dicarboxylate(912445-03-5)
• EPA Substance Registry System: (R)-2-benzyl 1-tert-butyl 2-methylpyrrolidine-1,2-dicarboxylate(912445-03-5)

Safety Data

• Hazardous Substances Data: 912445-03-5(Hazardous Substances Data)

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 

Downstream Products

• 166170-15-6 (R)-1-(tert-butoxycarbonyl)-2-methylpyrrolidine-2-carboxylic acid 
• 912444-00-9 veliparib 

Relevant articles and documents

Synthesis of (R)-Boc-2-methylproline via a Memory of Chirality Cyclization. Application to the Synthesis of Veliparib, a Poly(ADP-ribose) Polymerase Inhibitor

(R)-Boc-2-methylproline (3a) was synthesized in good yield with excellent stereochemical control from alanine benzyl ester hydrochloride 11. The process, which is based on a modification of one described by Kawabata, proceeds in four steps and requires no