166170-15-6

Basic information

• Product Name: (R)-N-BOC-2-methylproline
• Synonyms: (R)-N-BOC-2-methylproline;1-(tert-butoxycarbonyl)-2-methyl-D-proline(SALTDATA: FREE);1,2-Pyrrolidinedicarboxylic acid, 2-methyl-, 1-(1,1-dimethylethyl) ester, (2R)-;(2R)-2-Methyl-1,2-pyrrolidinedicarboxylic acid 1-(1,1-dimethylethyl) ester;1-Boc-2-Methyl-D-proline;(R)-1-Boc-2-Methyl-proline;Boc-α-Me-D-Pro-OH;(R)-1-(tert-Butoxycarbonyl)-2-Methylpyrrolidine-2-carboxylic acid
• CAS NO: 166170-15-6
• Molecular Formula: C₁₁H₁₉NO₄
• Molecular Weight: 229.28
• Product Categories: α-Methyl Amino Acids
• Mol File: 166170-15-6.mol
• Article Data: 6

Chemical Properties

• Melting Point: 127-129℃
• Boiling Point: 337.762 °C at 760 mmHg
• Flash Point: 158.073 °C
• Appearance: /
• Density: 1.160
• Storage Temp.: 2-8°C
• PKA: 4.20±0.20(Predicted)
• CAS DataBase Reference: (R)-N-BOC-2-methylproline(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-N-BOC-2-methylproline(166170-15-6)
• EPA Substance Registry System: (R)-N-BOC-2-methylproline(166170-15-6)

Safety Data

• Hazardous Substances Data: 166170-15-6(Hazardous Substances Data)

Usage

General Description

(R)-N-BOC-2-methylproline is a chemical compound also known as N-alpha-BOC-2-methyl-L-proline. It is a derivative of the amino acid proline and is commonly used in organic synthesis and peptide chemistry. The BOC (tert-butyloxycarbonyl) group protects the amine group of the proline, making it a valuable building block for the synthesis of complex peptides and proteins. (R)-N-BOC-2-methylproline is often used in the pharmaceutical industry for the development of new drugs and as a key intermediate in the synthesis of bioactive molecules. Additionally, (R)-N-BOC-2-methylproline is also used as a chiral auxiliary in asymmetric synthesis for the preparation of enantiomerically pure compounds.

Upstream product

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Downstream Products

• 1207754-99-1 tert-butyl (R)-2-(hydroxymethyl)-2-methylpyrrolidine-1-carboxylate 
• 912444-00-9 veliparib 
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Relevant articles and documents

ALKYNYL QUINAZOLINE COMPOUNDS

The present disclosure relates to compounds of Formula (I'): and pharmaceutically acceptable salts and stereoisomers thereof. The present disclosure also relates to methods of preparation these compounds, compositions comprising these compounds, and methods of using them in the prevention or treatment of abnormal cell growth in mammals, especially humans.

Synthetic method for novel chiral ligand, metal chelate, multiple unnatural amino acids, maraviroc and key intermediate thereof

The invention discloses a synthetic method for a novel chiral ligand, a metal chelate, multiple unnatural amino acids, maraviroc and a key intermediate thereof. According to the synthetic method, (R)-2-methylproline is selected as a starting material, and asymmetrical resolution is induced by utilizing a nickel chelate, so that (S)-beta3-amino acid is obtained, and (S)-3-amino-3-phenylpropionic acid is taken as the key intermediate for synthesizing maraviroc, so that yield is high, and ee value reaches more than or equal to 98.2%. The method disclosed by the invention has the advantages that source of raw materials is wide, conditions of a synthetic process are mild, control is easy, and optical purity of products is high.

Discovery of 2-alkyl-1-arylsulfonylprolinamides as 11β-hydroxysteroid dehydrogenase type 1 inhibitors

On the basis of scaffold hopping, a novel series of 2-alkyl-1- arylsulfonylprolinamides was discovered as 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD-1) inhibitors. A representative compound 4ek, obtained through SAR and structure optimization studies, demonstrates excellent in vitro potency against 11β-HSD-1 and dose-dependent in vivo inhibition of 11β-HSD-1 in a prednisone/prednisolone transformation biomarker study in mice.