912469-48-8

Upstream product

• 137898-13-6 2-trifluoromethylsulphonyloxy-3-methoxybenzaldehyde 
• 1066-54-2 trimethylsilylacetylene 
• 912469-32-0 3-methoxy-2-trimethylsilanylethynyl-benzoic acid methyl ester 
• 132338-45-5 methyl 3-methoxyl-2-(trifluoromethylsulfonyloxy)benzoate 
• 6342-70-7 3-methoxymethylsalicylate 

Downstream Products

• 1373444-00-8 2-(3-butynyl)-1-{[2-(3-butynyl)-6-methoxyphenyl]ethynyl}naphthalene 
• 912469-44-4 3-[2-(2-[1,3]dioxan-2-yl-6-methoxy-phenyl)-4,5-dimethoxy-naphthalen-1-yloxy]-propan-1-ol 
• 912469-52-4 C₂₅H₂₆O₇ 
• 912469-51-3 acetic acid 2-(2-[1,3]dioxan-2-yl-6-methoxy-phenyl)-4,5-dimethoxy-naphthalen-1-yl ester 
• 912469-38-6 7-(2-[1,3]dioxan-2-yl-6-methoxy-phenylethynyl)-5,8,8-trimethoxy-bicyclo[4.2.0]octa-1,3,5-trien-7-ol 
• 912469-37-5 2-(2-[1,3]dioxan-2-yl-6-methoxy-phenyl)-4,5-dimethoxy-naphthalen-1-ol 
• 912469-42-2 2-(1-acetoxy-4,5-dimethoxy-naphthalen-2-yl)-3-methoxy-benzoic acid methyl ester 
• 912469-41-1 acetic acid 2-(2-formyl-6-methoxy-phenyl)-4,5-dimethoxy-naphthalen-1-yl ester 
• 912469-35-3 2-(2-ethynyl-3-methoxy-phenyl)-[1,3]dioxane 
• 912469-50-2 2-ethynyl-3-methoxybenzaldehyde 
• 912469-49-9 3-methoxy-2-((trimethylsilyl)ethynyl)benzaldehyde 

Relevant academic research and scientific papers

Nickel-Catalyzed Construction of Chiral 1-[6]Helicenols and Application in the Synthesis of [6]Helicene-Based Phosphinite Ligands

Two 1-[6]helicenol derivatives were synthesized by Ni-catalyzed [2+2+2] cycloaddition on a multigram scale. Both enantiomers of the 1-[6]helicenols could be efficiently prepared by simple optical resolution. As a synthetic application of helically chiral 1-[6]helicenols, a novel class of [6]helicene-based phosphinites was developed; these compounds represent the first examples of helically chiral phosphinite ligands. Up to 90 % ee was obtained for the Pd-catalyzed asymmetric allylic alkylation reaction.

Convergence in [2+2+2] synthesis of β-phenylnaphthalene motif in polyaromatic natural products

Two optional routes to β-phenylnaphthalene structure are developed by introducing α- and β-styryl groups onto different positions in the benzocyclobutene ring followed by ring enlargement.